迟连利

男， 山东大学国家糖工程技术研究中心， 教授/研究员/教授级高工或同等级别

学习/工作经历

2010.02-今：山东大学国家糖工程技术研究中心，教授
2007.02-2010.02：美国雅培实验室，资深科学家
2005.05-2005.08：美国葛兰素史克公司，实习顾问
2003.09-2006.12：美国伦斯勒理工学院化学与化学生物系，博士
2002.08-2003.08：美国爱荷华大学药学院，博士研究生
1999.09-2002.06：中国海洋大学海洋药物与食品研究所，硕士
1995.09-1999.06：中国海洋大学食品科学与工程系，本科

研究领域和兴趣

糖药物、糖分析化学

主要业绩

迟连利，山东大学教授，博士生导师，泰山产业领军人才（2024），获张树政糖科学奖优秀青年奖（2017年）、张天民糖类药物奖杰出青年奖（2020年）、山东省科技进步二等奖（2019，2024）、山东省药学会科学技术奖一等奖（2022）等荣誉。在JACS, Anal Chem, JBC和MCP等国际知名期刊发表SCI论文70余篇，主持国家自然科学基金重大研究计划项目、面上项目和青年项目5项，负责国家重点研发计划子课题3项。主要从事多糖药物的科学研究及产业化技术开发，侧重于肝素类药物的结构解析、构效关系和质量控制研究，为我国肝素类糖药物的研发、质量提升和打入国际市场做出了突出贡献。

代表成果

[1] Z. An, Q. Chen, C. Bu, L. Chen, D. Shi, B. Zhang, L. Jin*, L. Chi*, Structural domain analysis of heparin and heparan sulfate combined with label-free quantitative proteomics to elucidate their functional diversity in liver cancer and APAP-induced liver injury, Molecular & Cellular Proteomics, 2025, 101090.
[2] B. Zhang, C. Bu, Q. Wang, Q. Chen, D. Shi, H. Qiu, Z. Wang, J. Liu, Z. Wang, Q. Zhang*, L. Chi*, Low molecular weight heparin promotes the PPAR pathway by protecting the glycocalyx of cells to delay the progression of diabetic nephropathy, Journal of Biological Chemistry, 2024, 300, 107493.
[3] Q. Chen, X. Xu, S. Xie, A. Sheng, N. Han, Z. Tian, X. Wang, F, Li, R.J. Linhardt, F. Zhang, L. Jin*, Q. Zhang*, L. Chi*, Improving impact of heparan sulfate on the endothelial glycocalyx abnormalities in atherosclerosis as revealed by glycan-protein interactome, Carbohydrate Polymers, 2024, 330, 121834.
[4] D. Shi, H. Zhao, C. Bu, K. Fraser, H. Wang, J.S. Dordick, R.J. Linhardt, F. Zhang*, F. Shi*, L. Chi*, New insights into the binding of PF4 to long heparin oligosaccharides in ultra-large complexes using mass spectrometry, Journal of Thrombosis and Haemostasis, 2023, 21, 3608-3618.
[5] D. Shi, A. Sheng, C. Bu, Z. An, X. Cui, X. Sun, H. Li, F. Zhang, R.J. Linhardt, T. Zhang*, L. Jin*, L. Chi*, A cluster sequencing strategy to determine the consensus affinity domains in heparin for its binding to specific proteins, Analytical Chemistry, 2022, 94, 13987-13994.
[6] A. Sheng, Q. Chen, M. Yu, R. Xiao, T. Zhang, Z. Wang, R. J. Linhardt, X. Sun*, L. Jin*, L. Chi*, Coupling liquid chromatography and tandem mass spectrometry to electrophoresis for in-depth analysis of glycosaminoglycan drugs: Heparin and the Multicomponent Sulodexide, Analytical Chemistry, 2021, 93, 1433-1442.
[7] Z. Wang, L. Chi*, Recent advances in mass spectrometry analysis of low molecular weight heparins, Chinese Chemical Letters, 2018, 29, 11-18.
[8] X. Sun, A. Sheng, X. Liu, F. Shi, L. Jin, S. Xie, F. Zhang, R. J. Linhardt, L. Chi*, Comprehensive identification and quantitation of basic building blocks for low-molecular weight heparin, Analytical Chemistry, 2016, 88, 7738-7744.
[9] D. Li, P. Zhang, F. Li, L. Chi, D. Zhu, Q. Zhang*, L. Chi*, Recognition of N-glycoforms in human chorionic gonadotropin by monoclonal antibodies and their interaction motifs, Journal of Biological Chemistry, 2015, 290, 22715-22723.
[10] L. Chi, J. Wolff, T. Laremore, O. Restaino, J. Xie, C. Schiraldi, T. Toida, J. Amster, R. J. Linhardt, Structural analysis of bikunin glycosaminoglycan, Journal of the American Chemical Society, 2008, 130, 2617-2625.

*以上信息由高级会员个人更新和维护。