唐翔鹰

男， 华中科技大学， 教授/研究员/教授级高工或同等级别

学习/工作经历

2001.7-2005.9，华中科技大学化学系，学士
2005.9-2010.7，中国科学院上海有机化学研究所，博士
2010.9-2012.8，美国叶史华大学爱因斯坦医学院，博士后
2012.11-2016.8，中国科学院上海有机化学研究所，金属有机化学国家重点实验室，副研究员
2016.9起，华中科技大学化学与化工学院, 教授、博士生导师

研究领域和兴趣

有机合成化学

主要业绩

系统研究了过渡金属卡宾生成的新方法、新模式以及转化新方法，开发了铑催化三氮唑开环再关环的方法，金催化的吲哚/联烯烃类衍生物的立体和区域选择性环加成反应，金催化的联烯环丙烷卡宾开环新模式，钌催化的1，3-炔亚胺的开环新模式，用于制备系列杂环化合物，包括Azepine、多取代吡咯、多取代噻吩等。最近，我们还发现通过可见光将邻二酮衍生物激发到三线态，可以直接与三芳基膦反应实现羰基脱氧产生卡宾，进而发生各类杂氢键的插入反应，同时，利用给反应可以实现多个天然产物和药物分子的简洁合成。这一新的卡宾生成模式无需产生氮气，无需合成重氮化合物前体，为卡宾化学的发展提供了新思路。

代表成果

1. Luo, Y.-X., Huang, J., Wu, G.-J., Tang, X.-Y., Qu, J.-P. Visible-light-mediated deoxygenative transformation of 1,2-dicarbonyl compounds through energy transfer process, Nat. Commun. 2024, 15, 10.1038/s41467-024-53635-1.
2. San, H. H., Wang, C.-Y., Zeng, H.-P., Fu, S.-T., Jiang, M., Tang, X.-Y. Boron-Catalyzed Azide Insertion of α-Aryl α-Diazoesters. Org. Lett., 2019, 84, 10.1021/acs.joc.8b03278.
3. Yuan, W., Huang, J., Xu, X., Wang, L., Tang, X.-Y. B(C6F5)3-Catalyzed Electron Donor-Acceptor Complex-Mediated Aerobic Sulfenylation of Indoles under Visible-Light Conditions. Org. Lett., 2021, 23, 10.1021/acs.orglett.1c02553.
4. Huang, J., Luo, Y.-X., Wang, L., Tang, X.-Y. Org. Lett., 2023, 25, 10.1021/acs.orglett.3c01977.
5. Wang, S.-J., Zhai, J.-J., Wang, L., Tang, X.-Y. Consecutive regulation of catalytic activities of B(C6F5)3•H2O: direct nucleophilic substitution of benzyl fluorides with alcohol via dual activation. Org. Chem. Front. 2023, 10, 10.1039/d3qo00737e.
6. Chen. G.-Q., Zhang, X.-N., Wei, Y., Tang, X.-Y., Shi, M. Catalyst-Dependent Divergent Synthesis of Pyrroles from 3-Alkynyl Imine Derivatives: A Noncarbonylative and Carbonylative Approach, Angew. Chem. Int. Ed., 2014, 53, 10.1021/jacs.5b02080.
7. Mei, L.-Y., Wei, Y., Tang, X.-Y., Shi, M. Catalyst-Dependent Stereodivergent and Regioselective Synthesis of Indole-Fused Heterocycles through Formal Cycloadditions of Indolyl-Allenes. J. Am. Chem. Soc., 2015, 137, 10.1021/jacs.5b02080.
8. Wang, Q., Tang, X.-Y., Shi, M. Metal-Free Cross-Coupling of Arylboronic Acids and Derivatives with DAST-Type Reagents for Direct Access to Diverse Aromatic Sulfinamides and Sulfonamides. Angew. Chem. Int. Ed., 2016, 55, 10.1002/anie.201605066.
9. Yang, J.-M., Zhu, C.-Z., Tang, X.-Y., Shi, M. Rhodium(II)-Catalyzed Intramolecular Annulation of 1-Sulfonyl-1,2,3Triazoles with Pyrrole and Indole Rings: Facile Synthesis of N-Bridgehead Azepine Skeletons. Angew. Chem. Int. Ed., 2014, 53, 10.1002/anie.201400881.
10. Chen, K., Zhu, Z.-Z., Zhang, Y.-S., Tang, X.-Y., Shi, M. Rhodium(II)-Catalyzed Intramolecular Cycloisomerizations of Methylenecyclopropanes with N-Sulfonyl 1,2,3-Triazoles. Angew. Chem. Int. Ed., 2014, 53, 10.1002/anie.201402803.

*以上信息由高级会员个人更新和维护。