柯国梁

男， 湖南大学化学化工学院， 教授/研究员/教授级高工或同等级别

学习/工作经历

2006.9-2010.6 厦门大学 理学学士
2010.9-2016.12 厦门大学 理学博士
2013.9-2015.11 美国亚利桑那州立大学 国家公派联合培养博士生
2017.1-至今 湖南大学 助理教授、副教授、教授

研究领域和兴趣

生物分析与生化传感

主要业绩

主要从事疾病诊疗新方法和DNA纳米技术研究：以功能核酸（核酸适体、脱氧核酶等）和DNA自组装纳米结构（DNA折纸、DNA纳米花等）为工具，结合小分子、蛋白质、纳米颗粒等材料，开展荧光生物探针、智能纳米机器、信号放大、药物递送等领域的研究，为疾病诊断和治疗提供新方法。主持国家优秀青年科学基金、湖南省杰出青年基金等，担任Analytical Chemistry, Exploration, Interdisciplinary Medicine等期刊青年编委，荣获湖南省化学化工学会青年化学奖等荣誉，以第一或通讯作者在Nat. Commun., Sci. Adv., J. Am. Chem. Soc., Angew. Chem. Int. Ed., Chem. Soc. Rev., Anal. Chem.等期刊上发表系列论文。

代表成果

1. L. L. Zhang; M. Chen; Z. Q. Wang; M. J. Zhong; H. Chen; T. Li; L. L. Wang; Z. H. Zhao; X. B. Zhang; G. L. Ke; Y. L. Liu; W. H. Tan, Spatiotemporal Regulation of Cell Fate in Living Systems Using Photoactivatable Artificial DNA Membraneless Organelles, ACS Central Science 2024 10, 1201-1210, 10.1021/acscentsci.4c00380.
2. G. Z. Li; C. Y. Chen; Y. Y. Li; B. Wang; J. L. Wen; M. Y. Guo; M. Chen; X. B. Zhang; G. L. Ke, DNA-Origami-Based Precise Molecule Assembly and Their Biological Applications, Nano Letters 2024 24, 11335-11348, 10.1021/acs.nanolett.4c03297.
3. Y. Y. Gao; C. N. Gong; M. Chen; S. Y. Huan; X. B. Zhang; G. L. Ke, Endogenous Enzyme-Driven Amplified DNA Nanocage Probe for Selective and Sensitive Imaging of Mature MicroRNAs in Living Cancer Cells, Analytical Chemistry 2024 96, 9453-9459, 10.1021/acs.analchem.4c00704.
4. T. Chen; X. J. Wang; R. R. Gao; M. H. Yuan; M. Chen; X. B. Zhang; G. L. Ke, Size-Selective Hybridization Chain Reaction for Accurate Signal Amplification in Living Cancer Cells, Science China-Chemistry 2024 67, 4259-4266, 10.1007/s11426-024-2294-x.
5. L. L. Zheng; J. Z. Li; M. Wen; D. M. Xi; Y. X. Zhu; Q. Wei; X. B. Zhang; G. L. Ke; F. Xia; Z. F. Gao, Enthalpy and Entropy Synergistic Regulation-Based Programmable DNA Motifs for Biosensing and Information Encryption, Science Advances 2023 9, eadf5868, 10.1126/sciadv.adf5868.
6. S. Zhao; S. H. Zhang; H. J. Hu; Y. C. Cheng; K. X. Zou; J. Song; J. Q. Deng; L. L. Li; X. B. Zhang; G. L. Ke; J. S. Sun, Selective In Situ Analysis of Mature microRNAs in Extracellular Vesicles Using a DNA Cage-Based Thermophoretic Assay, Angewandte Chemie-International Edition 2023 62, e202303121, 10.1002/anie.202303121.
7. Y. Yin; W. Xie; M. Y. Xiong; Y. Y. Gao; Q. Liu; D. Han; G. L. Ke; X. B. Zhang, FINDER: A Fluidly Confined CRISPR-Based DNA Reporter on Living Cell Membranes for Rapid and Sensitive Cancer Cell Identification, Angewandte Chemie-International Edition 2023 62, e202309837, 10.1002/anie.202309837.
8. G. Z. Kong; M. Y. Xiong; L. Liu; L. Hu; H. M. Meng; G. L. Ke; X. B. Zhang; W. H. Tan, DNA Origami-Based Protein Networks: From Basic Construction to Emerging Applications, Chemical Society Reviews 2021 50, 1846-1873, 10.1039/d0cs00255k.
9. X. Y. Fu; G. L. Ke; F. Q. Peng; X. Hu; J. Q. Li; Y. Y. Shi; G. Z. Kong; X. B. Zhang; W. H. Tan, Size-Selective Molecular Recognition Based on a Confined DNA Molecular Sieve Using Cavity-Tunable Framework Nucleic Acids, Nature Communications 2020 11, 1518, 10.1038/s41467-020-15297-7.
10. Y. H. Chen; G. L. Ke; Y. L. Ma; Z. Zhu; M. H. Liu; Y. Liu; H. Yan; C. J. Yang, A Synthetic Light-Driven Substrate Channeling System for Precise Regulation of Enzyme Cascade Activity Based on DNA Origami, Journal of the American Chemical Society 2018 140, 8990-8996, 10.1021/jacs.8b05429.

*以上信息由高级会员个人更新和维护。