黄静

女， 湖南大学， 教授/研究员/教授级高工或同等级别

学习/工作经历

2001-2005 湖南农业大学， 应用化学 本科；
2005-2010 武汉大学，化学生物学 博士；
2010-2015 美国国立卫生研究院， 博士后；
2016-2021 湖南大学生物学院，教授
2017至今 化学生物传感国家重点实验室，教授
2021至今 湖南大学生命医学交叉研究院，教授

研究领域和兴趣

生物大分子的化学调控与功能解析

主要业绩

黄静教授课题组的研究领域主要是通过化学工具和手段，对生物大分子进行修饰、调控；研究DNA从识别到修饰、从损伤到修复的过程。从分子水平研究细胞衰老、死亡的机理，为相关疾病靶向治疗提供理论基础和新思路。研究方向涉及化学生物学，细胞生物学，药学、基础医学等多学科的交叉。已在Molecular Cell, Angew. Chem. Int. Ed.，Cell Reports，Nucleic Acids Research，Journal of Medicinal Chemistry等国际期刊上发表论文50余篇。

代表成果

1. Jiangyu Yan, Lingli Bu, Yingsha Wang, Haojun Yao, Guorui Li, Kewei Zheng,* and Jing Huang*, Pyridine-bis(benzimidazole) induces DNA damage at G-quadruplex loci and promotes synthetic lethality with DNA repair inhibition, Nucleic Acids Research, 2025, 53, 12, gkaf543. doi.org/10.1093/nar/gkaf543
2. Xuzi Zhao, Shan Jiang, Jiangyu Yan, Lingli Bu, Guorui Li, Jing Huang*, Photocaged fluorescent probes for spatiotemporally monitoring G-Quadruplex DNA in live cells, Bioorganic Chemistry, 2025,160,108446. DOI: 10.1016/j.bioorg.2025.108446
3. Zhiming Xing, Jiangyu Yan, Yongxiang Miao, Yawen Ruan, Haojun Yao, Youkang Zhou, Yingqun Tang, Guorui Li*, Zhibin Song*, Yiyuan Peng, and Jing Huang*, Endoplasmic Reticulum-Targeting Quinazolinone-Based Lipophilic Probe for Specific Photoinduced Ferroptosis and Its Induced Lipid Dynamic Regulation, Journal of Medicinal Chemistry, 2024, 67, 3, 1900–1913. doi.org/10.1021/acs.jmedchem.3c01652
4. Jiahao Zhang, Haiyue Peng, Zi'an Chen, Guorui Li*, Jing Huang*, Photocaged activity-based probes for improved monitoring of protein S-sulfenylation in living cells, Chinese Chemical Letters, 2024, 35, 2, 108560. doi.org/10.1016/j.cclet.2023.108560
5. Xuzi Zhao, Ting Wang, Fucheng Shang, Jiangyu Yana, Mingyan Jiang, Xiaoyan Zou, Guorui Li*, Zhibin Song*, Jing Huang*, Coumarin-Quinazolinone based photosensitizers: Mitochondria and endoplasmic reticulum targeting for enhanced phototherapy via different cell death pathways, European Journal of Medicinal Chemistry, 2024, 280, 116990. doi.org/10.1016/j.ejmech.2024.116990
6. Haojun Yao, Song Liu, Zhiming Xing, Yongxiang Miao, Zhibin Song, Guorui Li, and Jing Huang*, Thionation toward High-Contrast ACQ-DIE Probes by Reprogramming the Aqueous Segregation Behavior: Enlightenment from a Sulfur-Substituted G-Quadruplex Ligand, Analytical Chemistry, 2022, 94, 15231−15239. doi.org/10.1021/acs.analchem.2c02388
7. Guorui Li#, Yi Yang #, Yaya Zhang, Peiling Huang, Jiangyu Yan, Zhibin Song, Quan Yuan，Jing Huang*，A Reactive Oxygen Species-Tyrosinase Cascade Activated Prodrug for Selectively Suppressing Melanoma，CCS Chemistry， 2022, 4 (5) , 1654-1670. doi.org/10.31635/ccschem.021.202101032
8. Haiyue Peng, Ting Wang, Guorui Li*, Jing Huang*, and Quan Yuan, Dual-Locked Near-Infrared Fluorescent Probes for Precise Detection of Melanoma via Hydrogen Peroxide-Tyrosinase Cascade Activation, Analytical Chemistry, 2022, 94, 2, 1070–1075. doi.org/10.1021/acs.analchem.1c04058
9. Song Liu, Lingli Bu, Yuming Zhang, Jiangyu Yan, Ling Li, Guorui Li *, Zhibin Song *, Jing Huang *, Subtle Structural Changes of Dyes Lead to Distinctly Different Fluorescent Behaviors in Cellular Context: The Role of G-Quadruplex DNA Interaction Using Coumarin-Quinazolinone Conjugates as a Case Study, Analytical Chemistry, 2021, 93, 12, 5267-5276. doi.org/10.1021/acs.analchem.1c00301

*以上信息由高级会员个人更新和维护。