林子俺

男， 福州大学化学学院， 教授/研究员/教授级高工或同等级别

学习/工作经历

1995.09-1998.06，福州大学化学系，工业分析专业，大专；
1998.07-2002.08，福州鼓楼铝合金厂，技术员；
2002.09-2007.06，福州大学，分析化学专业，硕博连读，理学博士；
2007.07-2009.06，南开大学化学学院，博士后（合作导师：张玉奎 中科院院士）；
2009.07-2014.08，福州大学化学化工学院，副研究员；
2014.09-2015.08，香港浸会大学理学院，博士后（合作导师：蔡宗苇 欧洲院士）；
2015.09-至今，福州大学化学学院，副研究员、研究员（2017.08-2017.09，香港浸会大学环境与生物分析国家重点实验室，高级访问学者）；

研究领域和兴趣

分析化学、复杂样品前处理、色谱、质谱、环境分析化学与毒理、疾病标志物筛查与诊断

主要业绩

面向环境与健康的国家战略需求，申请人从色谱和质谱的视角开展创新研究，综合运用组学、质谱成像、生物信息学和大数据分析等手段，发展新污染物与疾病标志物精准识别、去除富集、毒性评估以及筛查诊断的新技术、新方法、新装置。主要成果包括：1）提出了污染物、疾病标志物精准识别新策略，建立了基于先进材料驱动的复杂样品去除或富集新技术；2）开发了一系列新型分离媒介和色谱固定相，建立了基于色谱技术的污染物、蛋白质、多肽的高效、高通量、高选择分离新方法；3）搭建固相微萃取-常压电离质谱、表面增强激光解吸电离质谱成像等联用平台，开发了一系列具有高响应的质谱探针，实现环境代谢组学、疾病蛋白质组学的深度覆盖和精准鉴定。研究成果为解析污染物暴露与健康效应、揭示疾病发病机制以及实现精准诊疗提供科学依据。先后主持6项国家自然科学基金（5面上，1青基），获中国分析测试协会科学技术一等奖（2016）和特等奖（2020）；以第一或通讯作者身份发表SCI论文160余篇，包括J. Am. Chem. Soc., Adv. Mater., Adv. Funct. Mater., Environ. Sci. Technol., Chem. Sci., Mass Spec. Rev., Anal. Chem.,等，他引6500余次，H指数 46，多篇论文入选高被引、热点或封面文章，授权国家发明专利14项，2023和2024年度入选全球前2%顶尖科学家榜单。

代表成果

1. Wen Xie, Yajing Zhang, Yu He, Hang Su, Jinni Zhang, Canrong Chen, Peisi Xie, Jing Chen, Zian Lin, *, and Zongwei Cai, * Dietary Exposure to Imidacloprid at Environmental Doses Induces Renal Injury in Mice via P-AMPK Inhibition and Subsequent Purine Metabolism Dysregulation Environ. Sci. Technol. 2025, Accepted
2. Yuandi Xue#, Xian Chen#, Fan Wu, Canrong Chen, Na Lin, Shaofeng Dong, Ying Sun, Zian Lin* A Self-Oxidizing o-Dihydroxybenzene-Based Covalent Organic Framework Hydrogel with Broad-Spectrum Antibacterial Properties for Promoting Diabetic Wound Healing. Adv. Funct. Mater., 2025, 2505669
3.Fan Wu, Jin Liu, Qiuting Zhang, Yuandi Xue, Jingjing Yan, Kaixing Luo, Yanhui Zhong and Zian Lin* Capsule-type single-crystal covalent organic frameworks as an advanced chromatographic stationary phase for efficient separation of isomers. Anal Chem., 2025, 97(22), 11815-11823.
4.Akang Dan, Jiahao Yuan, Peisi Xie, Jing Chen, Canrong chen, Zian Lin*, Zongwei Cai* Chronic exposure to environmentally relevant doses of triphenyl phosphate induces anxiety- and depression-like behaviors in mice via the gut-brain axis. Environ. Sci. Technol.，2025, 59(27), 13671-13682.
5.Dan Ouyang, Chuanzhe Wang, Chao Zhong, Juan Lin, Gang Xu, Guane Wang* and Zian Lin* Organic Metal Chalcogenides-Assisted Metabolic Molecular Diagnosis of Central Precocious Puberty Chem Sci., 2024, 15, 278 - 284.
6.Qiong Zheng#, Jin Liu#, Yijing Wu, Yin Ji, and Zian Lin* Fluoro-functionalized Spherical Covalent Organic Frameworks as Liquid Chromatographic Stationary Phase for the High-resolution Separation of Organic Halides Anal. Chem., 2022, 94(51), 18067-18073.
7.Dan Ouyang, Qiong Zheng, Huan Huang, Zongwei Cai, and Zian Lin* Covalent Organic Framework Nanofilm-Based Laser Desorption/Ionization Mass Spectrometry for 5-Fluorouracil Analysis and Tissue Imaging. Anal. Chem., 2021, 93(47), 15573-15578.
8.Wende Ma, Qiong Zheng, Yanting He, Guorong Li, Wenjing Guo, Zian Lin*, and Lan Zhang* Size-controllable Synthesis of Uniform Spherical Covalent Organic Frameworks at Room Temperature for Highly Efficient and Selective Enrichment of Hydrophobic Peptides. J. Am. Chem. Soc., 2019, 141, (45), 18271-18277.
9. Zian Lin,* Jie Wu, Yongqiang Dong, Peisi Xie, Yanhao Zhang, and Zongwei Cai.* Nitrogen and Sulfur Co-doped Carbon Dots-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry Imaging for Profiling Bisphenol S Distribution in Mouse Tissues. Anal. Chem., 2018, 90(18), 10872-10880.
10.Yingxue Jin, Jingjing Yan Zongwei Cai, Zian Lin* Advances in Nanomaterials for Surface-Assisted Laser Desorption Ionization Mass Spectrometry: Applications in Small Molecule Analysis over the Past Five Years Trac-trend Anal Chem., 2025, 183, 118102.

*以上信息由高级会员个人更新和维护。