郭磊

女， 军事科学院军事医学研究院， 教授/研究员/教授级高工或同等级别

学习/工作经历

1993.09~1997.07 郑州大学化学系，化学学士；
1997.09~2000.07 中国科学院生态环境研究中心，分析化学硕士；
2000.09~2003.07 中国科学院化学研究所，分析化学博士；
2003.11~2004.12 德国莱比锡大学分析化学研究所，博士后；
2005.03~2009.06 原军事医学科学院，助理研究员，药物分析学，毒物药物分析；
2009.07~2017.12 原军事医学科学院，副研究员，药物分析学，毒物药物分析；
2017.12~今 军事科学院军事医学研究院，研究员，药物分析学，毒物药物分析。

研究领域和兴趣

毒物药物分析

主要业绩

国际禁化武组织科学咨询委员会委员，国家药监局化妆品技术规范委员会委员，中国分析测试协会常务理事、中国分析测试协会毒物分析专业委员会总干事，中国毒理学会中毒与救治专业委员会常务委员、人工智能毒理学专业委员会委员。获国家科技进步一等奖1项，中国分析测试协会科学技术奖特等奖1项。主持国家、军队重点项目等多项课题。第一/通讯作者发表SCI及核心期刊论文140余篇。主(参)编专著10部，授权国家发明专利12项。培养硕博士研究生40余名，指导研究生荣获全军优秀硕士学位论文1人次，军事科学院优秀硕士论文2人次、优秀博士论文1人次。

代表成果

1) Luyuan Qin, Yuxin Zhao, Meilian Tan, Deyun Tan, Jia Chen, Jinjuan Xue, Jianwei Xie,* Lei Guo*. An integrated data-mining strategy via transcriptomics and DIA quantitative proteomics to unveil chemical attribution signature peptides for tracing origins of castor beans. Anal. Chem. 98(21):15493-15507(2026), 10.1021/acs.analchem.6c00346
2) Huang Xuan, Yifan Zhao, Hongliang Li, Rui Xiao, Bo Ma, Jia Chen, Yulong Liu, Yanqin Liu, Linlin Kong, Jinjuan Xue, Jianfeng Wu, Zhiyong Nie, Zhi Li, Hua Xu, Jianwei Xie *, Lei Guo*. Screening and SPR-guided maturation of anti-ricin cyclononapeptide for high-sensitivity fluorescent LFA integrated with ultracompact handheld reader. Talanta 309:130005(2026), 10.1016/j.talanta.2026.130005
3) Kexin Li, Yulong Liu, Yanqin Liu, Qian Li, Lei Guo*, Jianwei Xie. The reactivation kinetic analysis, molecular docking, and dynamics of oximes against three V-type nerve agents inhibited four cholinesterases. Chem. Biol. Interact. 396:111061(2024), 10.1016/j.cbi.2024.111061
4)Luyuan Qin, Jiadong Huang, Yuanzhou Feng, Baoquan Zhao, Lei Guo*, and Jianwei Xie.Spatiotemporal visualization of paraquat distribution, toxicokinetics, and its detoxification in zebrafish using matrix-assisted laser desorption ionization mass spectrometry imaging. Chem. Res. Toxicol. 37(2):385-394(2024), 10.1021/acs.chemrestox.3c00338
5)Zhifang Yang, Chuang Wang, Jia Liu, Lan Xiao, Lei Guo*, Jianwei Xie.In silico–ex vitro iteration strategy for affinity maturation of anti-ricin peptides and the SPR biosensing application. Toxins 15: 490(2023), 10.3390/toxins15080490
6）Zhifang Yang#, Chenyu Wang#, Lan Xiao, Chuang Wang, Li Tang*, Lei Guo*, Jianwei Xie. SCX-tip-aided LC-MS detection of active ricin via oligonucleotide substrates for depurination kinetics. Analyst 148, 2782-2792(2023), 10.1039/d3an00217a
7）Luyuan Qin, Junshan Han, Chuang Wang, Bin Xu, Deyun Tan, Song He*, Lei Guo*, Xiaochen Bo, Jianwei Xie. Key defatting tissue pretreatment protocol for enhanced MALDI MS Imaging of peptide biomarkers visualization in the castor beans and their attribution applications. Frontiers Plant Sci.13:1083901(2022), 10.3389/fpls.2022.1083901
8）Dongmei Li, Zehua Li, Bin Xu, Jia Chen, Jinjuan Xue, Shundi Hu, Luhong Wen, Lei Guo*, Jianwei Xie, Guibin Jiang. Thermal desorption bridged the gap between dielectric barrier discharge ionization and dried plasma spot samples for sensitive and rapid detection of fentanyl analogs in mass spectrometry. Analyst 147:4187-4196(2022), 10.1039/d2an00946c
9）Lei Guo, Hua Xu, Jianwei Xie, Tomas Bergström, Martin Skiba, Martin Dorner, François Becher. Chapter V. Analysis of ricin: immunocapture. Recommended operating procedures for CWC-related analysis. Paula Vanninen Ed. University of Helsinki (ISBN 978-951-51-9959-1). 2023.pp787-799
(10)Lei Guo, Zhi Li, and Bo Ma, LIU Shi-Lei, LIU Chang-Cai, LIANG Long-Hui. Chapter VIII. Analysis of ricin: Functional testing. Recommended operating procedures for CWC-related analysis. Paula Vanninen Ed. University of Helsinki (ISBN 978-951-51-9959-1). 2023.pp867-884

*以上信息由高级会员个人更新和维护。