朱少林

男， 南京大学， 教授/研究员/教授级高工或同等级别

学习/工作经历

2001.09‒2005.07 本科，南京大学
2005.09‒2010.07 博士，中国科学院上海有机化学研究所（导师：马大为 研究员）
2010.11‒2013.01 博士后，普林斯顿大学（导师：David W. C. MacMillan）
2013.02‒2015.08 博士后，麻省理工学院（导师：Stephen L. Buchwald）
2015.9‒至今 教授，南京大学化学化工学院

研究领域和兴趣

合成化学，不对称催化

主要业绩

烯烃转化屡获诺奖青睐，是合成化学研究重要领域，兼具科研与产业价值。传统转化局限
于双键原位，需分离所需构型烯烃。申请人聚焦丰产金属镍催化烃类惰性位点转化，创新成果
包括：1）开发镍氢化学和迁移配体，构建迁移偶联新体系，突破烯烃原位官能团化局限，通
过多样性偶联位点和偶联试剂展示催化体系普适性；2）在连续1,2-Ni/H迁移基础上发展了空
间1,n-Ni/H迁移新模式，拓展烃类原料多样性；3）针对金属催化中活性和选择性精准调控难
题，提出配体接力催化新策略并用于迁移不对称偶联体系，简化配体并提高催化效率和选择性
，规避了传统多功能单配体设计难题。发表54篇通讯作者论文，授权4项专利，原创性工作受
到了国际同行的广泛关注和正面评价，开发的镍氢催化体系被全球30多个知名课题组跟踪研究
。未来拟探索丰产金属迁移新模式和催化新策略，多技术融合加速催化剂创制，实现从基础化
学键构建到功能分子创制和精细化学品经济性生产。

代表成果

1. You Wang; Yuli He; Shaolin Zhu ; Nickel-Catalyzed Migratory Cross-Coupling Reactions: New
Opportunities for Selective C–H Functionalization, Accounts of Chemical Research, 56 (23) (2023), DOI: 10.1021/acs.accounts.3c00540.
2. You Wang; Yuli He; Shaolin Zhu ; NiH-Catalyzed Functionalization of Remote and Proximal
Olefins: New Reactions and Innovative Strategies, Accounts of Chemical Research, 55 (23) (2022), DOI:
10.1021/acs.accounts.2c00628.
3. Chen, Jian; Zhu, Shaolin ; Nickel-Catalyzed Multicomponent Coupling: Synthesis of α-
Chiral Ketones by Reductive Hydrocarbonylation of Alkenes, Journal of the American Chemical
Society, 143 (35) (2021), DOI: 10.1021/jacs.1c07851.
4. He, Yuli; Börjesson, Marino; Song, Huayue; Xue, Yuhang; Zeng, Daning; Martin, Ruben; Zhu,
Shaolin ; Nickel-Catalyzed Ipso/Ortho Difunctionalization of Aryl Bromides with Alkynes and Alkyl
Bromides via a Vinyl-to-Aryl 1,4-Hydride Shift, Journal of the American Chemical Society,
143 (48) (2021), DOI: 10.1021/jacs.1c10368.
5. Zhang, Yao; Ma, Jiawei; Chen, Jian; Meng, Lingpu; Liang, Yong; Zhu, Shaolin ; A relay
catalysis strategy for enantioselective nickel-catalyzed migratory hydroarylation forming chiral
alpha-aryl alkylboronates, Chem, 7 (11) (2021), DOI: 10.1016/j.chempr.2021.10.015.
6. Xiaoli Jiang; Feng-Tao Sheng; Yao Zhang; Gao Deng; Shaolin Zhu ; Ligand Relay Catalysis
Enables Asymmetric Migratory Reductive Acylation of Olefins or Alkyl Halides, Journal of the
American Chemical Society, 144 (47) (2022), DOI: 10.1021/jacs.2c10785.
7. Shi-Chao Wang; Lin Liu; Mei Duan; Weijia Xie; Jiabin Han; Yuhang Xue; You Wang; Xiaotai
Wang; Shaolin Zhu ; Regio- and Enantioselective Nickel-Catalyzed Ipso- and Remote Hydroamination
Utilizing Organic Azides as Amino Sources for the Synthesis of Primary Amines, Journal of the
American Chemical Society, 146 (44) (2024), DOI: 10.1021/jacs.4c12324.
8. Chen, Changpeng; Xu, Hanhong; Zhu, Shaolin ; Polarity-Reversed Functionalization of
Aliphatic Aldehydes via Divergent Nickel Hydride Catalysis, Angewandte Chemie-international
Edition, 64 (5) (2025), DOI: 10.1002/anie.202419965.
9. Jian Chen; Lifu Wu; Zhiyong Song; Yi Wang; Zhenkun Li; You Wang; Shaolin Zhu ; Cobalt-
Catalyzed Asymmetric Migratory Nozaki–Hiyama–Kishi Coupling, Journal of the American Chemical
Society, 146 (38) (2024), DOI: 10.1021/jacs.4c07910.
10. Jingjie Yang; Zhuofan Gui; Yuli He; Shaolin Zhu ; Functionalization of Olefinic C−H
Bonds by an Aryl‐to‐Vinyl 1,4‐Nickel Migration/Reductive Coupling Sequence, Angewandte Chemie
International Edition, 62 (28) (2023), DOI: 10.1002/anie.202304713.

*以上信息由高级会员个人更新和维护。