游常军

男， 湖南大学化学化工学院， 教授/研究员/教授级高工或同等级别

学习/工作经历

1999-2003 华中农业大学植物科学技术学院 本科
2003-2009 华中农业大学生命科学技术学院 博士
2009-2014 美国加州大学河滨分校化学系 博士后
2014-2017 美国加州大学河滨分校化学系 助理专家
2017至今 湖南大学化学化工学院 教授、博士生导师

研究领域和兴趣

生命分析化学与化学生物学

主要业绩

主讲《化学生物学》、《波谱分析》、《仪器分析实验》等研究生与本科生课程，作为编委和主编之一分别编写了普通高等教育“十一五”国家级规划教材《分析化学》、《化学生物学实验》和国家级线上一流本科课程配套教材《波谱分析》。主要从事生物分析化学、化学生物学与分子医学等多学科交叉领域的研究，利用生物质谱以及相关的化学生物学新工具，研究核酸化学修饰在遗传信息传递过程中的生物学效应及调控机制，从分子水平上探讨癌症等疾病发生发展及耐药的机制，为疾病诊疗和新药研发提供理论和技术基础。目前已在Anal. Chem., Acc. Chem. Res., Nat. Chem. Biol., Nat. Protoc., Nucleic Acids Res., PNAS等学术期刊发表论文40余篇。

代表成果

1. Zheng, X., Kong, W,. Dai, X*., You, C.* YBX1 modulates 8-oxoguanine recognition and repair in DNA. ACS Chemical Biology, 2025, 20: 529-536.
2. Zheng, X., Chang, S,. Liu, Y,. Dai, X*., You, C.* Human mitochondrial protein HSPD1 binds to and regulates the repair of deoxyinosine in DNA. Journal of Proteome Research, 2023, 22: 1339-1346.
3. Zheng, X., Chen, D., Zhao, Y., Dai, X*., You, C.* Development of an endonuclease V-assisted analytical method for sequencing analysis of deoxyinosine in DNA. Analytical Chemistry, 2022, 94: 11627-11632.
4. Yang, Y., Wang, Z,. Wang, J,. Dai, X*., You, C.* Next-generation sequencing-based analysis of the effects of N1- and N6-methyldeoxyadenosine adducts on DNA transcription. Analytical Chemistry, 2022, 94: 11248-11254.
5. Liu, Y., Zhu, X,. Wang, Z,. Dai, X*., You, C.* Next-generation sequencing-based analysis of the roles of DNA polymerases ν and θ in the replicative bypass of 8-oxo-7,8-dihydroguanine in human cells. ACS Chemical Biology, 2022, 17: 2315-2319.
6. Liu, Y., Qu, M,. Pan, M., Zheng, X., Sheng, Y., Ji, Y., You, C*., Dai, X.* Chemical proteomic profiling of UTP-binding proteins in human cells.Analytica Chimica Acta, 2021, 1168: 338607.
7. You, C., Dai, X., Wang, Y*. Position-dependent effects of regioisomeric methylated adenine and guanine ribonucleosides on translation. Nucleic Acids Research, 2017, 45: 9059-9067.
8. You, C., Wang, Y*. Mass spectrometry-based quantitative strategies for assessing the biological consequences and repair of DNA adducts. Accounts of Chemical Research, 2016, 49: 205-213.
9. You, C., Wang, Y*. Quantitative measurement of transcriptional inhibition and mutagenesis induced by site-specific DNA lesions in vitro and in vivo. Nature Protocols, 2015, 10: 1389-1406.
10. You, C., Dai, X., Yuan, B., Wang, J., Wang, J., Brooks, P., Niedernhofer, L., Wang, Y*. A quantitative assay for assessing the effects of DNA lesions on transcription. Nature Chemical Biology, 2012, 8, 817-822.

*以上信息由高级会员个人更新和维护。