甘秀海

男， 贵州大学， 教授/研究员/教授级高工或同等级别

学习/工作经历

2019年11月至今 贵州大学 教授
2017年7月毕业于贵州大学 植物调控化学与生物学专业(博士)
2009年7月-2019年10月 贵州师范学院，助教、讲师、副教授、教授
2009年7月毕业于贵州大学 有机化学专业(硕士)
1998年7月-2006年9月 湖南省新晃县教育局，中学教师
1998年7月毕业于怀化学院 化学教育专业

研究领域和兴趣

药物合成

主要业绩

入选贵州省“省管专家”、贵州省“百人”，“优青科”及千层次创新型人才计划；贵州省服务地方经济专家库及贵州省科技专家库专家、中国植物病理学会线虫专业委员会委员，中国药学会高级会员、中国化学会及中国植物保护学会会员。主持国家重点研发计划课题、国家自然科学基金及省部级项目10余项。参编专著1部，发表论文100余篇，SCI收录论文50余篇，其中在农业科学领域TOP一区期刊ACS Catal.、Chinese Chem. Lett.、Sci. China. Chem.、J. Agric. Food Chem.、Pest Manag. Sci.等国际期刊发表40余篇，授权发明专利10余件，获国家科技进步二等奖1项，大北农科技奖一等奖1项。

代表成果

Tai, G.Y.; He, J.Q.; Zhang, W.; Liu, L.; Gan, X.H.* Identification of novel pyrazole-diphenyl ether hybrids as potential HPPD/PPO dual-target inhibitors. J. Agric. Food Chem. 2025, 73, 22218−22229.
Yan, Y.W.; Geng, W.; Chen, C.; Yan, K.;* Gan, X.H.* Novel phenylpyrazole derivatives containing carbonic ester moieties as protoporphyrinogen IX oxidase inhibitors. J. Agric. Food Chem. 2025, 73, 22150−22161.
Geng, W.; Zhang, W.; Lei, Q.; Gan, X.H.* Discovery of N‑phenylphthalimides containing ether moiety as potential protoporphyrinogen IX oxidase inhibitors. J. Agric. Food Chem. 2025, 73, 6599−6609.
Geng, W.; Lei, Q.; Zhang, W.; Gan, X.H.* Discovery of novel N-phenylphthalimide protoporphyrinogen IX oxidase inhibitors. J. Agric. Food Chem. 2025, 73, 4585−4593.
Zhang, W.; Yang, J.S.; Tang, X.Y.; Zhang, J.H.; Gan, X.H.* Novel N-phenyltriazinone derivatives containing oxazine/oxime fragments as promising protoporphyrinogen IX oxidase inhibitors. J. Agric. Food Chem. 2025, 73, 14857−14866.
Peng, J.; Zhou, L.L.; Chen, J.X.;* Hu, D.Y.;* Gan, X. H.* Zein and resveratrol Schiff base nanocomplexes: An efficient delivery system to enhance the antibacterial efficacy of berberine. Int. J. Biol. Macromol. 2025, 306, 141496.
Ndikuryayo, F.; Gong, X.Y.; Gan, X.H.*; Yang, W.C*. Assessing emerging contaminants in soils using soil enzyme-based methods: A critical review. Trends Environ. Anal. 2025, 46, e00260.
Zhang, W.; Zhang, J.H.; Yan, C.H.; Li, Y.; Gan, X.H.* Novel N phenyltriazinone carboxylic acid derivatives as promising protoporphyrinogen IX oxidase inhibitors. J. Agric. Food Chem. 2025, 73, 3908−3917.
Chen, C.; Geng, W.; Li, K; Lei, Q.; Jin, Z.C.;* Gan, X.H.* Pyridazine: A privileged scaffold in the development of 21st-century pesticides. Chinese Chem. Lett. 2025, 36, 110902.
Guo, X.; Ou, Y.Q.; Zhang, Q.; Li.Y.; Hao, H.H.; Yu, X.Y.; Huang, W.K.;* Gan, X.H.* Nematicidal activities and preliminary mechanisms of action of natural quinones against plant parasitic nematodes. Pestic. Biochem. Phys. 2025, 213, 106499.
Zhang, Q.; Liu, D.; Ou, Y.Q.; Gan, X.H.* 1,2,4-Oxadiazole-5-carboxylic acid derivatives as safe seed treatment nematicides. J. Agric. Food Chem. 2025, 73, 169−179.
Ou, Y.Q.; Guo, X.; Zhang, Q.; Zhang, W.; Gan, X.H.* Design, synthesis, and nematicidal activity of novel 1,2,4 oxadiazole derivatives containing amide fragments. Mol. Divers. 2025, 29, 2293–2304.
Wang, Q.Q.; Zhang, W.; Gan, X.H.* Design, synthesis, and herbicidal activity of natural naphthoquinone derivatives containing diaryl ether structures. J. Agric. Food Chem. 2024, 72, 17200−17209.
Wang, Q.Q.; Zhang, W.; Zhong, F.P.; Yang, W.C.; Gan, X.H.* Virtual screening for the discovery of lawsone derivatives as PS Ⅱ inhibitors. Arab. J. Chem., 2024, 17, 105985.
Geng, W.; Zhang, Q.; Liu, L.; Tai, G.Y.; Gan, X.H.* Design, synthesis, and herbicidal activity of novel tetrahydrophthalimide derivatives containing oxadiazole/thiadiazole moieties. J. Agric. Food Chem., 2024, 72, 17191−17199.
Peng, J.; Zhang, Y.; Yang, J.G.; Zhou, L.L.; Zhang, S.D.; Wu, X.; Chen, J.X.; Hu, D.Y.;* Gan, X.H.* Novel trans-resveratrol derivatives: Design, synthesis, antibacterial activity, and mechanisms. J. Agric. Food Chem. 2024, 72, 15561−15571.
Zhang, W.; Zhang, J.H.; Yan, C.H.; Gan, X.H.* Discovery of Novel N‑phenyltriazinone derivatives containing oxime ether or oxime ester moieties as promising protoporphyrinogen IX pxidase inhibitors. J. Agric. Food Chem. 2024, 72, 12946−12955.
Tai, G.Y.; Zhang, Q.; He, J.Q.; Li, X.Y.;* Gan, X.H.* Ferulic acid dimers as potential antiviral agents by inhibiting TMV self-assembly. J. Agric. Food Chem. 2024, 72, 14610−14619.
Chen, C.; Lei, Q.; Geng, W.; Wang, D.P.;* Gan, X.H.* Discovery of novel pyridazine herbicides targeting phytoene desaturase with scaffold hopping. J. Agric. Food Chem. 2024, 72, 12425−12433.
Zhang, Y.; Cai, H.; Gan, X.H.;* Jin, Z.C.* N-Heterocyclic carbene-catalyzed enantioselective (dynamic) kinetic resolutions and desymmetrizations. Sci. China. Chem., 2024, 67, 482–511.
Hu, S.H.; Yang, L.L.; Yan, C.; Xiao, Y.N. Jin, Z.J.; Gan, X.H.;* Zhang, B.;* Wu, W.N.* pH and redox dual-responsive ZIF-8-based nanoplatform for targeted pathogens and environmental protection. Chem. Eng. J. 2024, 498, 154844.
Song, C.Y.; Pang, C.; Deng, Y.L.; Cai, H.; Gan, X.H.;* Y.G.R. Chi.* Catalytic N-acylation for access to N–N atropisomeric N-aminoindoles: Choice of acylation reagents and mechanistic insights. ACS Catal. 2024, 14, 6926−6935.
Lan, S.C.; Zhang, W.; Gan, X.H.* Novel 1-indanone derivatives containing oxime and oxime ether moieties as immune activator to resist plant virus. Pest Manag. Sci., 2023, 79, 2686–2695.
Zhong, F.P.; Zhang, Q.; Chen, K.J.; Lan, S.C.; Yang, W.C.;* Gan, X.H.* Eco-friendly cinnamic acid derivatives containing glycoside scaffolds as potential antiviral agents. J. Agric. Food Chem. 2023, 71, 17752−17762.
Lian, L.; Wang, H.Z.; Zhang, F.W.; Liu, W.T.; Lu, X.T.; Jin, T.; Wang, J.X.; Gan, X.H;* Song, B.A.* Cypyrafluone, a 4‑hydroxyphenylpyruvate dioxygenase inhibitor to control weed in wheat fields. J. Agric. Food Chem. 2023, 71, 8825−8833.
Zeng, H.N; Zhang, W.; Wang, Z.X.; Gan, X.H.* Discovery of novel pyrazole derivatives with improved crop safety as 4‑hydroxyphenylpyruvate dioxygenase-targeted herbicides. J. Agric. Food Chem., 2023, 71, 3950−3959.
Gan, X.H.*; Zhang, W.; Lan, S.C.; Hu, D.Y.* Novel cyclized derivatives of ferulic acid as potential antiviral agents through activation of photosynthesis. J. Agric. Food Chem., 2023, 71, 1369−1380.
代表性发明专利
甘秀海, 耿望, 邰钢银, 张琪, 章伟, 陈超, 姜孟帆. 一种含N-苯基亚胺类衍生物及其制备方法及应用. 授权号: ZL202310659084.9 授权日期: 2025.08.29.
甘秀海, 兰世超, 章伟. 一种茚酮衍生物及其合成方法和应用. 授权号: ZL202310152679.5, 授权日期: 2024.08.20.
甘秀海, 刘丹, 王正兴, 梁峻铖, 王清清. 3-取代-1,2,4-噁二唑-5-羧酸类衍生
物、其制备方法及应用. 授权号: ZL 202210487758.7, 授权日期: 2023.10.20.
甘秀海, 袁婷, 韦兴品, 陈超, 兰世超. 一种含酰胺的阿魏酸衍生物及其制备方法和应用. 授权号: ZL 202111547205.8, 授权日期: 2023.10.20.
甘秀海, 刘丹, 袁婷, 宋宝安, 胡德禹. 阿魏酸丁香酚及异丁香酚杂合体及应用. 中国发明专利, 授权号: ZL 202110836762.5, 授权日期: 2023.07.28.
甘秀海, 刘丹, 曾华南, 袁婷, 王正兴, 梁峻铖, 罗领, 耿望. 含1,3,4-噻二唑单元的1,2,4-噁二唑衍生物及其制备方法与应用. 中国发明专利, 授权号: ZL 202111555676.3, 授权日期: 2023.06.30.
甘秀海, 罗领, 刘丹. 一种含卤烷基的1,2,4-噁二唑衍生物及其制备方法与应用. 中国发明专利, 授权号: ZL202210697466.6, 授权日期: 2023.04.07.
甘秀海, 袁婷, 刘丹, 宋宝安, 胡德禹. 一种含哌嗪的阿魏酸衍生物、其制备方法及应用. 中国发明专利, 授权号: ZL202110775583.5, 授权日期: 2022.11.01.
甘秀海, 刘丹, 王正兴, 曾华南, 袁婷, 梁峻铖, 罗领, 耿望. 1,2,4-噁二唑-5-甲酰胺类衍生物及其制备方法与应用. 中国发明专利, 授权号: ZL202111553516.5, 授权日期: 2022.10.25.
Gan, Xiuhai; Wang, zhengxing; Yuan, Ting; Liu, Dan; Zeng, Huanan. Ferulic acid derivative containing eugenol(isoeugenol) as well as preparation method and application thereof. 南非发明专利, 授权号: 2022/02218, 授权日期: 2022.06.29.
甘秀海, 宋宝安, 胡德禹, 吴剑, 张建, 陈吉祥. 超声波辅助酶法提取的百尾参多糖、其方法及应用. 中国发明专利, 授权号: ZL201911281242.1, 授权日期: 2021.07.09.

*以上信息由高级会员个人更新和维护。