汪铭

男， 中国科学院化学研究所， 教授/研究员/教授级高工或同等级别

学习/工作经历

1999-2003 安庆师范大学 学士
2003-2006 北京师范大学 硕士
2006-2009 中国科学院化学研究所 博士
2009-2011 美国犹他大学 博士后
2011-2016 美国塔夫茨大学 博士后
2016-至今 中国科学院化学研究所 研究员

研究领域和兴趣

化学生物学；药物递送

主要业绩

长期致力于蛋白质化学生物学与载体化学生物学研究。聚焦活体层次蛋白质功能的时空选择性调控，建立了系列蛋白质靶向递送新技术，揭示了蛋白质弱键自组装及载体界面化学在细胞与组织水平调控蛋白质递送时空选择性的规律。提出基于超分子多级自组装的靶向嵌合体设计策略，通过精准调控蛋白质空间邻近效应，实现了时空特异性蛋白质降解及翻译后修饰，为神经退行性疾病和肿瘤等重大疾病的化学干预及靶向治疗提供了新手段。

代表成果

1. Ji Liu, Tianyu Ma, Rui Yao, Lijuan Li, Qizhen Zheng, Ming Wang*, Multimodal supramolecular targeting chimeras enable spatiotemporally resolved protein degradation In Vivo, Cell, 2026, 189,1108-1123.
2. Qizhen Zheng, Rui Yao, Tianyu Ma, Lijuan Li, Ying jiang*, Ming Wang*, Spatiotemporally resolved protein tagging for dynamic and tissue-specific secretome profiling in vivo, Angew. Chem. Int. Ed, 2026, 65, e5498199.
3. Tianyu Ma, Rui Yao, Qingyan Zhang, Ming Wang*, Molecular engineering of the Nano-Bio interface for programmable and precision protein delivery, Adv. Mater., 2026, 38, 1902575.
4. Ji Liu, Qizheng Zheng, Rui Yao, Ming Wang*, Lung-specific supramolecular nanoparticles for efficient delivery of therapeutic proteins and genome editing nucleases, Proc. Natl. Acad. Sci. USA., 2024, 121, 2406654121.
5. Lijuan Li, Tianyu Ma, Ming Wang*, Protein-integrated hydrogen-bonded organic frameworks: chemistry and biomedical applications, Angew. Chem. Int. Ed, 2024, 63, e202400926.
6. Qizhen Zheng, Tianyu Ma, Ming Wang*, Unleashing the power of proenzyme delivery for targeted therapeutic applications using biodegradable lipid nanoparticles, Acc. Chem. Res., 2024, 57, 208-221.
7. Jiakang Tang, Ji Liu, Qizhen Zheng, Rui Yao, Ming Wang*, Neuroprotective bioorthogonal catalysis in mitochondria using protein-integrated hydrogen-bonded organic frameworks, Angew. Chem. Int. Ed., 2023, 62, e202312784.
9. Weiqi Cai, Ji Liu, Xianghan Chen, Lanqun Mao, Ming Wang*, Orthogonal chemical activation of enzyme-Inducible CRISPR/Cas9 for cell-selective genome editing, J. Am. Chem. Soc. 2022, 144, 22272-22280.
9. Tianli Luo, Qizhen Zheng, Leihou Shao, Tianyu Ma, Lanqun Mao, Ming Wang*, Intracellular delivery of glutathione peroxidase degrader induces ferroptosis in vivo, Angew. Chem. Int. Ed., 2022, 61, e202206277.
10. Ji Liu, Jinhang Sheng, Leihou Shao, Qizhen Zheng, Wenting Li, Xianghan Chen, Lanqun Mao, Ming Wang*, Tetraphenylethylene-featured fluorescent supramolecular nanoparticles for intracellular trafficking of protein delivery and neuroprotection. Angew. Chem. Int. Ed., 2021, 60, 26740-26746.

*以上信息由高级会员个人更新和维护。