李子福

男， 华中科技大学生命科学与技术学院， 教授/研究员/教授级高工或同等级别

学习/工作经历

2004/09-2008/06：华中科技大学（学士）
2008/08-2012/06：香港中文大学（博士）
2012/08-2013/02：香港中文大学（研究助理）
2013/03-2015/01：加拿大阿尔伯塔大学（博士后）
2015/02-2016/01：美国佐治亚理工学院（研究科学家）
2016/02-迄今：华中科技大学（教授）

研究领域和兴趣

纳米药物

主要业绩

李子福，华中科技大学三级教授、博士生导师、华中卓越特聘教授，入选国家高层次青年人才、湖北省海外高层次人才、华中科技大学学术前沿青年团队项目、Biomaterials Science 2023年Emerging Investigators，作为负责人领衔中央高校优秀青年团队培育项目，以核心骨干身份入选科技部重点领域创新团队（肿瘤纳米医药技术创新团队），研究方向为生物力纳米肿瘤学。担任国家药品注册审评专家咨询委员会专家、“湖北省生物无机化学与药物”重点实验室及“生物医用与防护材料湖北省工程研究中心”副主任，被选为中国抗癌协会纳米肿瘤学青年委员会常委、中国药学会药剂学青年委员会委员、中国毒理学会纳米毒理学专业委员会委员、中国免疫学会肿瘤免疫及生物治疗专业委员会委员。在Nature Communications, Angewandte Chemie International Edition, Advanced Functional Materials, Advanced Science, Biomaterials, Chemical Society Reviews, Accounts of Chemical Research等期刊发表 SCI 论文100余篇，他引5000余次，H因子43，申请中国发明专利30件（其中已授权25件），申请PCT国际专利5项、美国专利1项，参编英文专著2部，主持国家自然科学基金项目4项、参与科技部重点研发计划项目2项，研究工作获临床试验伦理批件2项。

代表成果

1. Zheng Li, Chen Xiao, Xiangliang Yang, Zifu Li. Progress in the mechanical properties of nanoparticles for tumor-targeting delivery. Chemical Society Reviews, 2025, DOI: 10.1039/d3cs00912b
2. Qingyuan Deng, Ao Hua, Shiyou Li, Zhijie Zhang, Xiang Chen, Qiang Wang, Xing Wang, Zhiqin Chu, Xiangliang Yang, Zifu Li. Hyperbaric oxygen regulates tumor pH to boost copper-doped hydroxyethyl starch conjugate nanoparticles against cancer stem cells. Exploration, 2025, e20240080
3. Zhijie Zhang, Qingfu Zhao, Qingqing Xu, Qingyuan Deng, Ao Hua, Xing Wang, Xiangliang Yang, Zifu Li. A mitochondria-interfering nanocomplex cooperates with photodynamic therapy to boost antitumor immunity. Biomaterials, 2025, 317, 123094
4. Chen Xiao, Xing Wang, Shiyou Li, Zhijie Zhang, Jiayuan Li, Qingyuan Deng, Xiang Chen, Xiangliang Yang, Zifu Li. A cuproptosis-based nanomedicine suppresses triple negative breast cancers by regulating tumor microenvironment and eliminating cancer stem cells. Biomaterials, 2025, 122763
5. Zitao Fan, Xing Wang, Xiangliang Yang, Zifu Li. Boosting oxidative stress with hydroxyethyl starch smart nanomedicines to eliminate cancer stem cells. Accounts of Materials Research, 2024, 5, 12, 1558-1570
6. Xiang Chen, Zhengtao Yong, Yuxuan Xiong, Hai Yang, Chen Xu, Xing Wang, Qingyuan Deng, Jiayuan Li, Xiangliang Yang, Zifu Li. Hydroxyethyl starch conjugates co-assembled nanoparticles promote photodynamic therapy and antitumor immunity by inhibiting antioxidant systems. Asian Journal of Pharmaceutical Sciences, 2024, 19, 5, 100950
7. Yuxuan Xiong, Zhengtao Yong, Qingfu Zhao, Ao Hua, Xing Wang, Xiang Chen, Xiangliang Yang, Zifu Li. Hydroxyethyl starch-based self-reinforced nanomedicine inhibits both glutathione and thioredoxin antioxidant pathways to boost reactive oxygen species-powered immunotherapy. Biomaterials, 2024, 122673
8. Qiang Wang, Shiyou Li, Chen Xu, Xing Wang, Tian Yang, Chong Wang, Yuxuan Xiong, Zhijie Zhang, Xiangliang Yang, Zifu Li. Glutaminolysis inhibition boosts photodynamic therapy to eliminate cancer stem cells. Biomaterials, 2024, 306, 122497
9. Zheng Li, Yabo Zhu, Zhijie Zhang, Huimin Wang, Chong Wang, Chen Xu, Shiyou Li, Shuya Zhang, Xiangliang Yang, Zifu Li. Softness-aided mild hyperthermia boosts stiff nanomedicine by regulating tumor mechanics. Advanced Science, 2024, 2306730
10. Chen Xiao, Jiayuan Li, Ao Hua, Xing Wang, Shiyou Li, Zheng Li, Chen Xu, Zhijie Zhang, Xiangliang Yang, Zifu Li. Hyperbaric oxygen boosts antitumor efficacy of copper-diethyldithiocarbamate nanoparticles against pancreatic ductal adenocarcinoma by regulating cancer stem cell metabolism. Research, 2024, 0335

*以上信息由高级会员个人更新和维护。