钱志勇

男， 四川大学， 教授/研究员/教授级高工或同等级别

学习/工作经历

1993-1997年: 四川大学，化学纤维专业，本科学生（工学学士）
1997-2000年: 四川大学，材料学专业，工学硕士，导师：吴大诚教授
2000-2003年: 中科院成都有机化学研究所，高分子化学专业，理学博士，导师：刘孝波教授
2003-2005年: 四川大学，材料学专业，博士后，合作导师：涂铭旌教授，中国工程院院士
2005 - 至今： 四川大学，华西医院生物治疗国家重点实验室，教授
2015 - 至今： 四川大学，二级教授

研究领域和兴趣

高分子材料；生物材料；纳米生物材料；药物递送；组织工程；肿瘤治疗

主要业绩

钱志勇，博士，四川大学二级教授/博导，国家杰出青年基金获得者、国家“万人计划”科技创新领军人才，中国医药生物技术协会纳米生物技术分会主任委员，四川大学华西医院生物治疗国家重点实验室纳米生物医学研究室主任。担任J Biomed Nanotechnol期刊主编，担任Signal Transduction and Targeted Therapy期刊副主编、 Chinese Chemical Letters期刊副主编、J Biological Engineering期刊副主编。主要研究方向是纳米生物材料的构建及其在肿瘤治疗和组织修复中的应用基础研究，以通讯/共同通讯作者身份在Adv Funct Mater, Adv Sci, ACS Nano, Acta Pharm Sinica B, Chin Chem Lett等国内外知名学术期刊发表学术论文100余篇，被他引6000余次。有两组专利技术与企业达成转让协议，其中“注射用多西他赛聚合物胶束”和“注射用紫杉醇聚合物胶束”已经获得2项药物临床试验批件。以第一完成人身份获得2019年度高等学校科学研究优秀成果奖（科学技术）自然科学奖一等奖，以第一完成人身份获得成都市自然科学奖，并获得四川省青年科技奖、获得2019年度“药明康德生命化学研究奖学者奖”，入选中国化学快报主办的第一届CCL优秀青年学者。

代表成果

一，论文:
1. Y. Chen, J. Zhang, X. Liu, S. Wang, J. Tao, Y. Huang, W. Wu, Y. Li, K. Zhou, X. Wei*, S. Chen, X. Li, X. Xu, L. Cardon, Z. Qian*, M. Gou*, Noninvasive in vivo 3D bioprinting. Science Advances. 6 (2020), eaba7406
2. Xinlong He, Ying Hao, Bingyang Chu, Yun Yang, Ao Sun, Kun Shi, Chengli Yang, Kai Zhou, Ying Qu, He Li, and Zhiyong Qian*. Redox-Activatable Photothermal Therapy and Enzyme-Mediated Tumor Starvation for Synergistic Cancer Therapy. Nano Today. 39 (2021), 101174
3. Qianjun He*, Shengrong Guo, Zhiyong Qian*, Xiaoyuan Chen*. Development of individualized anti-metastasis strategies by engineering nanomedicines. Chem Soc Review. 44 (2015), 6258-6286
4. Jinfeng Liao, Ruxia Han, Yongzhi Wu, Zhiyong Qian*. Review of a new bone tumor therapy strategy based on bifunctional biomaterials. Bone Research. 9 (2021), 18
5. Jinrong Peng, Yao Xiao, Qian Yang, Qingya Liu, Yu Chen, Kun Shi, Ying Hao, Zhiyong Qian*. Intracellular Aggregation of Peptide-Reprogrammed Small Molecule Nanoassemblies Enhances Cancer Chemotherapy and Combinatorial Immunotherapy. Acta Pharm Sinica B. 11 (2021), 1069-1082
6. Yan Yu, Jingrong Peng, Meng Pan, Yang Ming, Yan Li, Liping Yuan, Qingya Liu, Ruxia Han, Ying Hao, Yun Yang, Danrong Hu, He Li, Zhiyong Qian*. A Nonenzymatic Hydrogen Peroxide Electrochemical Sensing and Application in Cancer Diagnosis. Small Methods. 5 (2021), 2001212
7. Xiaohan Zhou, Xinlong He, Kun Shi, Liping Yuan, Yun Yang, Qingya Liu, Yang Ming, Cheng Yi, Zhiyong Qian*. Injectable Thermosensitive Hydrogel containing Erlotinib-loaded Hollow Mesoporous Silica Nanoparticles as Localized Drug Delivery System for NSCLC Therapy. Adv Sci. 7 (2020), 2001442
8. Kun Shi, Bingxin Xue, Yanpeng Jia, Liping Yuan, Ruxia Han, Fan Yang, Jinrong Peng, and Zhiyong Qian*. Sustained co-delivery of gemcitabine and cis-platinum via biodegradable thermo-sensitive hydrogels for synergistic combination therapy of pancreatic cancer. Nano Research. 12 (2019), 1389–1399
9. Jinrong Peng #, Qian Yang #, Yao Xiao, Kun Shi, Qingya Liu, Ying Hao, Fan Yang, Ruxia Han, Zhiyong Qian*. Tumor Microenvironment Responsive Drug-Dye-Peptide Nanoassembly for Enhanced Tumor-Targeting, Penetration, and Photo-Chemo-Immunotherapy. Adv Funct Mater. 29 (2019), 1900004
10. Wei Chen,# Ting Huang,# Kun Shi, Bingyang Chu, Zhiyong Qian*. Chemotaxis-based self-accumulation of surface-engineered mitochondria for cancer therapeutic improvement. Nano Today. 35 (2020), 100966
11. Bingyang Chu, Ying Qu, Xinlong He, Ying Hao, Chengli Yang, Yun Yang, Danrong Hu, Fangfang Wang, Zhiyong Qian*. ROS-responsive camptothecin prodrug nanoparticles for on-demand drug release and combination of chemotherapy and photodynamic therapy. Adv Funct Mater. 30 (2020), 2005918
12. Ying Hao, Yuwen Chen, Xinlong He, Yongyang Yu, Ruxia Han, Yang Li, Chengli Yang, Danrong Hu, ZhiYong Qian*. Polymeric Nanoparticles with ROS-Responsive Prodrug and Platinum Nanozyme for Enhanced Chemophotodynamic Therapy of Colon Cancer. Adv Sci. 7 (2020), 2001853
13. YanPeng Jia, Kun Shi, Fan Yang, JinFeng Liao, RuXia Han, LiPing Yuan, Ying Hao, Meng Pan, Yao Xiao, ZhiYong Qian*, XiaWei Wei*. Multifunctional Nanoparticle Loaded Injectable Thermoresponsive Hydrogel as NIR Controlled Release platform for Local Photothermal Immunotherapy to Prevent Breast Cancer Postoperative Recurrence and Metastases. Adv Fucnt Mater. 30 (2020), 2001059
14. Jinrong Peng, Yao Xiao, Wenting Li, Qian Yang, Liwei Tan, Yanpeng Jia, Ying Qu, Zhiyong Qian*. Photosensitizer micelles together with IDO inhibitor Enhance Cancer Photothermal Therapy and Immunotherapy. Adv Sci. 5 (2018), 1700891
15. Ruxia Han, Yao Xiao, Qian Yang, Meng Pan, Ying Hao, XinLong He, JinRong Peng*, Zhiyong Qian*. Ag2S Nanoparticle-mediated Multiple Ablations Reinvigorates the Immune Response for Enhanced Cancer Photo-immunotherapy. Biomaterials. 264 (2021), 120451
16. Tianlin Zhou, Jinrong Peng, Ying Hao, Kun Shi, Kai Zhou, Yun Yang, Chengli Yang, Xinlong He, Xinmian Chen, and Zhiyong Qian*. The construction of a lymphoma cell-based, DC-targeted vaccine, and its application in lymphoma prevention and cure. Bioactive Materials. 6 (2021), 697-711
17. Fan Yang, Kun Shi, Ying Hao, Yanpeng Jia, Qingya Liu, Yu Chen, Meng Pan, Liping Yuan, Yongyang Yu*, and Zhiyong Qian*. Cyclophosphamide loaded thermo-responsive hydrogel system synergize with a hydrogel cancer vaccine to amplify personalized cancer immunotherapy in a prime-boost manner. Bioactive Materials. 6 (2021), 3036-3048
18. DanRong Hu, Lin Zhong, MengYao Wang, HaoHuan Li, Ying Qu, QingYa Liu, RuXia Han, LiPing Yuan, Kun Shi, JinRong Peng, ZhiYong Qian*. Perfluorocarbon-loaded and redox-activatable photosensitizing agent with oxygen supply for enhancement of fluorescence/photoacoustic imaging guided tumor photodynamic therapy. Adv Funct Mater. 29 (2019), 1806199
19. Qian Yang#, Jinrong Peng#, Kun Shi, Yao Xiao, Qingya Liu, Ruxia Han, Xiawei Wei, Zhiyong Qian*. Rationally designed peptide-conjugated gold/platinum nanosystem with active tumor-targeting for enhancing tumor photothermal-immunotherapy. J Control Rel. 308 (2019), 29–43
20. Ying Qu#, Bingyang Chu#, Minyi Lei, Danrong Hu, Ruoyu Zha, Lin Zhong, Mengyao Wang, Zhiyong Qian*. Redox/pH dual-stimuli responsive camptothecin prodrug nanogels for “on-demand” drug delivery. J Control Rel. 296 (2019), 93-106
21. Chengli Yang, Yuyin Fu, Cheng Huang, Danrong Hu, Kai Zhou, Ying Hao, Bingyang Chu, Xiaohan Zhou, Zhiyong Qian*. Chlorin e6 and CRISPR-Cas9 Dual-Loading System with Deep Penetration for a Synergistic Tumoral Photodynamic-Immunotherapy. Biomaterials. 255 (2020), 120194
22. Ao Sun, Xinye He, Lang Li, Tao Li, Qinya Liu, Xinli Zhou, Xiao Ji, Wei Li, Zhiyong Qian*. An injectable Photopolymerized hydrogel with Antimicrobial and biocompatible properties for infected skin Regeneration. NPG Asia Materials. 12 (2020), 25
23. Liping Yuan, Minyi Lei, Xingli Zhou, Danrong Hu, Qingya Liu, Meng Pan, Yu Chen, Wei Li, ZhiYong Qian*. A Novel Composite of Micelles and Hydrogel for Improving Skin Delivery of Hydrocortisone and Application in Atopic Dermatitis Therapy. Appl Mater Today. 19 (2020), 100593
24. Fan Yang, Kun Shi, Yanpeng Jia, Ying Hao, Jinrong Peng, Yao Xiao, Liping Yuan, ZhiYong Qian*. A biodegradable thermosensitive hydrogel vaccine for cancer immunotherapy. Appl Mater Today. 19 (2020), 100608
25. Yu Chen, Yi Lu, Danrong Hu, Jinrong Peng, Yao Xiao, Ying Hao, Meng Pan, Liping Yuan, and Zhiyong Qian * Cabazitaxel loaded MPEG-PCL copolymeric nanoparticles for enhanced colorectal cancer therapy. Appl Mater Today. 25 (2021), 101210
26. Wenting Li#, Bingxin Xue#, Kun Shi, Ying Qu, Bingyang Chu, Zhiyong Qian *. Magnetic iron oxide nanoparticles/10-hydroxy camptothecin co-loaded nanogel for enhanced photothermal-chemo therapy. Appl Mater Today. 14 (2019), 84–95
27. Xichuan Tang#, Liwei Tan#, Kun Shi, Jinrong Peng, Yao Xiao, Wenting Li, Lijuan Chen, Qian Yang, Zhiyong Qian*. Gold nanorods together with HSP inhibitor-VER-155008 micelles for colon cancer mild-temperature photothermal therapy. Acta Pharmaceut Sinica B. 8 (2018), 587–601
28. WenTing Li, JinRong Peng, LiWei Tan, Jing Wu, Kun Shi, Ying Qu,XiaWei Wei, Zhiyong Qian*. Mild Photothermal Therapy/Photodynamic Therapy/Chemotherapy of Breast Cancer by Lyp-1 Modified Docetaxel/IR820 Co-loaded Micelles. Biomaterials. 106 (2016), 119-133
29. Ying Qu#, BingYang Chu#, JinRong Peng, JinFeng Liao, TingTing Qi, Kun Shi, HuaPing Zhang, XiaoNing Zhang, Zhiyong Qian*. A biodegradable thermo-responsive hybrid hydrogel: therapeutic applications in preventing the post-operative recurrence of breast cancer. NPG Asia Materials. 7 (2015), e207
30. MaLing Gou#, Ke Men#,Juan Zhang#, YuHua Li, Jia Song, Shan Luo, HuaShan Shi,YanJun Wen, Gang Guo, MeiJuan Huang, Xia Zhao, ZhiYong Qian*, YuQuanWei. Efficient Inhibition of C-26 Colon Carcinoma by VSVMP Gene Deliveredby Biodegradable Cationic Nanogel Derived from Polyethyleneimine.ACS Nano. 4 (2010), 5573-5584
31. Fang Fang#, ChangYang Gong#, ZhiYong Qian*(通讯作者), XiaoNing Zhang, MaLing Gou, Chao You, LiangXueZhou, JiaGang Liu, Yu Zhang, GangGuo, YingChun Gu, Feng Luo, LiJuan Chen, Xia Zhao, YuQuan Wei. Honokiol Nanoparticles in Thermosensitive Hydrogel: Therapeutic Effects on Malignant Pleural Effusion. ACS Nano. 3 (2009), 4080-4088
32. ShaoZhi Fu, PeiYan Ni, BeiYu Wang, BingYang Chu, JinRong Peng, Lan Zheng, Xia Zhao, Feng Luo, YuQuan Wei, ZhiYong Qian*(通讯作者). In vivo biocompatibility and osteogenesis of electrospun Poly(ε-caprolactone)-Poly(ethylene glycol)-Poly(ε-caprolactone)/nano-hydroxyapatite composite scaffold. Biomaterials. 33 (2012), 8363-8371
33. ShaoZhi Fu, PeiYan Ni, BeiYu Wang, BingYang Chu, Lan Zheng, Feng Luo, JingCong Luo, ZhiYong Qian*(通讯作者). Injectable and thermo-sensitive PEG-PCL-PEG copolymer/Collagen/n-HA hydrogel composite for guided bone regeneration. Biomaterials.33 (2012), 4801-4809
34. ChangYang Gong, Bing Yang, ZhiYong Qian*, Xia Zhao, QinJie Wu, XiaoRong Qi, YuJun Wang, Gang Guo, Bing Kang, Feng Luo, YuQuan Wei. Improving Intraperitoneal Chemotherapeutic Effect and Preventing Postsurgical Adhesions Simultaneously with biodegradable micelles. Nanomedicine-Nanotechnology Biology and Medicine. 8 (2012), 963-973
35. Shuai Shi, Kun Shi, LiWei Tan, Ying Qu, GuoBo Shen, Bingyang Chu, Shuang Zhang, XiaoLan Su, XingYi Li, YuQuan Wei, ZhiYong Qian*. The use of cationic MPEG-PCL-g-PEI micelles for co-delivery of Msurvivin T34A gene and doxorubicin. Biomaterials. 35 (2014), 4536-4547
36. Mei Dai, Xu Xu, Jia Song, ShaoZhi Fu, MaLing Gou, Feng Luo, ZhiYong Qian*(通讯作者). Preparation of camptothecin-loaded PCEC microspheres for the treatment of colorectal peritoneal carcinomatosis and tumor growth in mice. Cancer Letters. 312 (2011), 189-196
37. ChangYang Gong, Shuai Shi, Lan Wu, MaLing Gou, QinQin Yin,QingFa Guo, PengWei Dong, Fan Zhang, FengLuo, Xia Zhao,YuQuan Wei, ZhiYong Qian* (通讯作者). Biodegradable in situ gel-forming controlled drug delivery system based on thermosensitive PCL-PEG-PCL hydrogel. Part 2: Sol-gel-sol transition and drug delivery behavior. Acta Biomater. 5 (2009), 3358-3370
38. YuJun Wang, LiJuan Chen, LiWei Tan, Qian Zhao, BingYang Chu, Feng Luo, ZhiYong Qian*. PEG-PCL based micelle hydrogels as oral docetaxel delivery systems for breast cancer therapy. Biomaterials. 35 (2014), 6972-6985
39. ChangYang Gong, QinJie Wu, YuJun Wang, DouDou Zhang, Feng Luo, Xia Zhao, YuQuan Wei, ZhiYong Qian*. A biodegradable hydrogel system containing curcumin encapsulated in micelles for cutaneous wound healing. Biomaterials. 34 (2013), 6377-6387
40. JinRong Peng, TingTing Qi, JinFeng Liao, BingYang Chu, Qian Yang, WenTing Li, Ying Qu, Feng Luo, ZhiYong Qian*. Controlled Release of Cisplatin from pH-Thermal Dual Responsive Nanogels. Biomaterials. 34 (2013), 8726-8740

二、专利：
1. 钱志勇，魏于全，赵霞。一种温度敏感型三嵌段共聚物及其制备方法和用途。中国发明专利，2008年申请、申请号：200810300751.X；2011年授权、专利号：ZL 200810300751.X
2. 钱志勇，魏于全，赵霞。具溶胶-凝胶转变特性的温敏性三嵌段共聚物及制备方法。中国发明专利，2008年申请、申请号：200810300757.7；2011年授权，专利号：ZL 200810300757.7。
3. 钱志勇，魏于全，赵霞，邓洪新。可降解PCFC-PEI聚合物、制备方法及在药物传递系统中的用途。中国发明专利，2009年申请，申请号：200910308100.X；2011年授权、专利号：ZL200910308100.X。
4. 钱志勇，魏于全，王成，赵霞。负载他克莫司或其药用盐的胶束和冻干制剂、制法及应用。中国发明专利，2011年申请，申请号：201110139610.6；2012年授权、专利号：ZL 201110139610.6。
5. 钱志勇，魏于全，王成，赵霞。二嵌段聚合物负载紫杉烷类药物的胶束和冻干制剂、制法及应用。中国发明专利，2011年申请，申请号：201110139616.3；2012年授权、专利号：ZL 201110139616.3。
6. 钱志勇，魏于全，王成，赵霞。三嵌段聚合物负载紫杉烷类药物的胶束和冻干制剂、制法及应用。中国发明专利，2011年申请，申请号：201110139775.3；2012年授权、专利号：ZL 201110139775.3。
7. 魏于全，钱志勇，杨莉，赵霞。PEG-PCL-PEG的新用途及装载抗原的混合物。中国发明专利，2010年申请，申请号：201010241625.9；2012年授权、专利号：ZL201010241625.9。
8. 钱志勇，魏于全，赵霞。MPEG-PLA两嵌段共聚物在制备医用防粘连材料中的用途。中国发明专利，2010年申请，申请号：201010133541.3；2012年授权、专利号：ZL 201010133541.3。
9. 钱志勇，魏于全，赵霞，巩长旸。PCL-PEG-PCL三嵌段共聚物在制备医用防粘连材料中的用途。中国发明专利，2010年申请，申请号：201010138739.0；2013年授权、专利号：ZL 201010138739.0。
10. 钱志勇，魏于全，苟马玲，赵霞。一种时间-温度变色指示器及其应用和使用方法。中国发明专利，2011年申请，申请号：201110167000.7；2013年授权、专利号：ZL 201110167000.7。
11. 钱志勇，魏于全。PDLLA-PEG-PDLLA三嵌段共聚物在制备医用防粘连材料中的用途。中国发明专利，2013年申请，专利号：ZL 201310185030.X。2015年3月4日授权；
12. 钱志勇，罗静聪，杨志明，赵霞，魏于全。一种复合材料及其制备方法和用途。中国发明专利，2012年申请，申请号：201210253461.0；2015年授权、专利号：ZL201210253461.0。
13. 赵杭，钱志勇，魏霞蔚。MPEG-PTMC两嵌段共聚物载药胶束及其制备方法和应用。中国发明专利，2016年申请，申请号：201610006593.1；2019年授权、专利号：ZL 201610006593.1。

三、著作
1. Ying Qu, XiaWei Wei, Zhiyong Qian*. “Thermosensitive Biomaterials in Tissue Engineering”. Chapter 15 in RSC Smart Materials No. 24. Smart Materials for Tissue Engineering: Fundamental Principles. Edited by Qun Wang. © The Royal Society of Chemistry 2017. Published by the Royal Society of Chemistry
2. XiaWei Wei, Gang Guo, ChangYang Gong, MaLing Gou, and Zhiyong Qian (通讯作者)*. “Biodegradable polymers: Research and Applications”. Chapter 12 in the book of “A Handbook of Applied Biopolymer Technology: Synthesis, Degradation and Applications” (RSC Green Chemistry Series). 2011, ISBN: 978-1-84973-151-5. Editors: SK Sharma and Ackmez Mudhoo. RSC Publisher, United Kingdom.
3. ChangYang Gong, Shuai Shi, PengWei Dong, MaLing Gou, XingYi Li, YuQuan Wei and ZhiYong Qian (通讯作者)*, A Novel Thermosensitive Composite Hydrogel Based on Poly(ethylene glycol)-poly(ε-caprolactone)-poly(ethylene glycol) (PECE) Copolymer and Pluronic F127. Chapter 2 in the book of “Polymer Aging, Stabilizers and Amphiphilic Block Copolymers” (“Polymer Science and Technology Series”). Editors: Liudvikas Segewicz and Marijus Petrowsky. Nova Publishers.页: 29-43，出版年: 2010 （ISBN: 978-1-60692-928-5）

*以上信息由高级会员个人更新和维护。