张闯年

男， 中国医学科学院生物医学工程研究所， 教授/研究员/教授级高工或同等级别

学习/工作经历

2024.12至今，生物医学工程研究所，生物材料研究部，研究员
2017.09-2024.11，生物医学工程研究所，药物控释实验室，副研究员
2015.08-2017.07，北京协和医学院，博士后，合作导师：孔德领 教授
2011.07-2015.07，天津市天思高分子材料技术开发有限公司研发部，研发人员
2006.09-2011.06，南开大学，高分子化学与物理，博士，导师：袁直 教授
2002.09-2006.06，辽宁师范大学，化学教育，学士

研究领域和兴趣

生物医用材料

主要业绩

作为项目骨干，入选了2017年天津市创新人才推进计划重点领域创新团队：“免疫活性生物材料创新团队”、2018年天津市人才发展特殊支持计划高层次创新创业团队：“组织修复生物活性材料创新团队”、2019年天津市创新人才推进计划重点领域创新团队：“兽用药物与诊断技术创新团队”和2020年天津市创新人才推进计划重点领域创新团队：“植介入生物医用材料创新团队”。团队研究成果“用于生物活性物质递送的纳米和水凝胶载体的构建和应用”获得2018年度天津市科学技术进步二等奖（王伟伟、黄平升、孔德领、董岸杰、张建华、张闯年、张超、邓联东）。团队研究成果“可吸收免疫调控生物材料的构建与应用”获得2024年度天津市科学技术进步二等奖（王伟伟、冯祖建、陈小刚、黄平升、张闯年）。

代表成果

科研论文：
(1)Y. Gao, Y. Li, N. Jiang, R. Gao, Y. Zhang, Z. Feng, C. Zhang*, L. Wang, W. Wang*, D. Kong, P. Huang*, Anti-inflammatory itaconate-loaded, cell-adhesive peptide-conjugated artificial small diameter vascular grafts for blood vessel regeneration, Acta Biomaterialia. 2025, doi: 10.1016/j.actbio.2025.06.034.
(2)Z. Chen, X. Lan, E. Zhu, J. Liu, C. Zhang, Research Progress of Sodium Alginate-Based Hydrogels in Myocardial Infarction Treatment, Tissue Engineering Part B-Reviews. 2025, Aug 7. doi: 10.1177/19373341251364282.
(3) H. Li, L. Ma, N. Zhu, X. Liang, K. Liu, X. Fu, C. Zhang*, J. Yang*, Natural-origin bioadhesive hydrogel with dual antioxidative and immunoregulatory properties for enhanced angiogenesis and wound healing, Bioactive Materials. 2025, 53, 507-521.
(4)Q.-H. Yang, C.-N. Zhang*, Comparative study on the pathogenesis of Crohn’s disease and ulcerative colitis, World Journal of Gastroenterology. 2025, 31(19), 106406.
(5)R. Xu, E. Zhu, X. Lan, Q. Yang, C. Zhang*, Mitochondrial targeted prodrug nanoparticles for chemo-photodynamic combinational tumour therapy, Smart Materials in Medicine. 2024, 5(3), 373-385.
(6) X. Chen, C. Xu, P. Zhao, Y. Zhang, J. Guo, X. Hu, H. Gao, C. Zhang*, X. Qu*, J. Zhang*, A multichannel Ca2+ nanomodulator amplifies exogenous and endogenous calcium overload for efficient antitumor and antimetastasis therapy, Chemical Engineering Journal. 2023, 463, 142478.
(7)Feng Zujian, Li Qinghua, Li Shuangyang, Zhang Yushan, Liu Xiang, Zhang Chuangnian*, Dong Anjie, Kong Deling, Wang Weiwei*, Huang Pingsheng*. Flexible and Zwitterionic Fluorinated Hydrogel Scaffold with High Fluorine Content for Noninvasive 19F Magnetic Resonance Imaging under Ultrahigh Scanning Resolution. Advanced Healthcare Materials. 2023, 12(16), 2201894.
(8)Li Huiyang, Liang Xiaoyu, Chen Youlu, Liu Kaijing, Fu Xue, Zhang Chuangnian*, Wang Xiaoli, Yang Jing*. Synergy of antioxidant and M2 polarization in polyphenol-modified konjac glucomannan dressing for remodeling wound healing microenvironment. Bioengineering & Translational Medicine. 2023, 8(2), e10398.
(9)Tang Jianghai, Chen Xuanjin, Shi Hang, Zhang, Mingming, Zhou Zhimin, Zhang Chuangnian*, Ke Tingyu, Kong Deling, Li Chen*. Prebiotic inulin nanocoating for pancreatic islet surface engineering. Biomaterials Science. 2023, 11(4): 1470-1485.
(10)Li Xiaomin, Yu Licheng, Zhang Chuangnian*, Niu Xiaoyan, Sun Mengjie, Yan Zichao, Wang Wei, Yuan Zhi*. Tumor acid microenvironment-activated self-targeting & splitting gold nanoassembly for tumor chemo-radiotherapy. Bioactive Materials. 2022, 7: 377-388.
(11)Pei Mengyue, Li Huiyang, Zhu Yingwei*, Lu Jian, Zhang Chuangnian*. In vitro evidence of oncofetal antigen and TLR-9 agonist co-delivery by alginate nanovaccines for liver cancer immunotherapy. Biomaterials Science. 2022, 10(11): 2865-2876.
(12)Qu Yue, Shi Hang, Liu Mohan, Zhang Mingming, Wang Hai, Pang Liyun, Zhang Chuangnian*, Kong Deling, Li, Chen*. In Vivo Insulin Peptide Autoantigen Delivery by Mannosylated Sodium Alginate Nanoparticles Delayed but Could Not Prevent the Onset of Type 1 Diabetes in Nonobese Diabetic Mice. Molecular Pharmaceutics. 2021, 18(4): 1806-1818.
(13)Zhang Chuangnian#, Dong Ying#, Gao Jing, Wang Xiaoli*, Jiang Yanjun*. Radial porous SiO2 nanoflowers potentiate the effect of antigen/adjuvant in antitumor immunotherapy. Frontiers of Chemical Science and Engineering. 2021, 15(5): 1296-1311.
(14)Pei Mengyue, Xu Rong, Zhang Chuangnian*, Wang Xiaoli, Li Chen, Hu Yunzhang*. Mannose-functionalized antigen nanoparticles for targeted dendritic cells, accelerated endosomal escape and enhanced MHC-I antigen presentation. Colloids and Surfaces B: Biointerfaces. 2021, 197, 111378.
(15)Pei Mengyue, Liang Jiayi, Zhang Chao, Wang Xiaoli*, Zhang Changnian*, Ma Guilei, Sun Hunfan. Chitosan/calcium phosphates nanosheet as a vaccine carrier for effective cross-presentation of exogenous antigens. Carbohydrate Polymers. 2019, 224: 115172.
(16)Zhang Xiaolei#, Zhang Chuangnian#, Cheng Mingbo, Zhang Yahui, Wang Wei, Yuan Zhi*. Dual pH-responsive “charge-reversal like” gold nanoparticles to enhance tumor retention for chemo-radiotherapy. Nano Research. 2019, 12(11): 2815-2826.
(17)Zhang Chuangnian#, Zhang Jimin#, Qin Yibo, Song Huijuan, Huang Pingsheng, Wang Weiwei, Wang Chun, Li Chen, Wang Yanming*, Kong Deling*. Co-delivery of doxorubicin and pheophorbide A by pluronic F127 micelles for chemo-photodynamic combination therapy of melanoma. Journal of Materials Chemistry B. 2018, 6(20): 3305-3314.
(18)Qin Yibo, Yang Pengxiang, Shi Shengbin, Sun Hongfan, Zhang Chuangnian*, Kong Deling*. Redox-sensitive Alginate Prodrug Nanoparticles for Tumor Photodynamic Therapy. Acta Polymerica Sinica. 2018, 7: 909-916.
(19)Zhang Chuangnian#, Shi Gaona#, Zhang Ju, Song Huijuan, Niu Jinfeng, Shi Shengbin, Huang Pingsheng, Wang Yanming, Wang Weiwei, Li Chen*, Kong Deling*. Targeted antigen delivery to dendritic cell via functionalized alginate nanoparticles for cancer immunotherapy. Journal of Controlled Release. 2017, 256: 170-181.
(20)Zhang Chuangnian, Shi Gaona, Zhang Ju, Niu Jinfeng, Huang Pingsheng, Wang Zhihong, Wang Yanming, Wang Weiwei, Li Chen*, Kong Deling*. Redox- and light-responsive alginate nanoparticles as effective drug carriers for combinational anticancer therapy. Nanoscale. 2017, 9(9): 3304-3314.
(21)Zhang Chuangnian#, Zhang Ju#, Shi Gaona, Song Huijuan, Shi Shengbin, Zhang Xiuyuan, Huang Pingsheng, Wang Zhihong, Wang Weiwei, Wang Chun*, Kong Deling*, Li Chen. A Light Responsive Nanoparticle-Based Delivery System Using Pheophorbide A Graft Polyethylenimine for Dendritic Cell-Based Cancer Immunotherapy. Molecular Pharmaceutics. 2017, 14(5): 1760-1770.
(22)Shi Gaona#, Zhang Chuangnian#, Xu Rong, Niu Jinfeng, Song Huijuan, Zhang Xiuyuan, Wang Weiwei, Wang Yanming, Li Chen*, Wei Xiaoqing*, Kong Deling*. Enhanced antitumor immunity by targeting dendritic cells with tumor cell lysate-loaded chitosan nanoparticles vaccine. Biomaterials. 2017, 113: 191-202.
(23)Zhang Chuangnian, Wang Wei, Liu Tong, Wu Yukun, Guo Hua, Wang Ping, Tian Qin, Wang Yongming, Yuan Zhi*. Doxorubicin-loaded glycyrrhetinic acid-modified alginate nanoparticles for liver tumor chemotherapy. Biomaterials. 2012, 33(7): 2187-2196.
(24)Zhang Chuangnian, Wang Ping, Lai Quanyong, Zhang Qian, Zhang Yue, Wu Yukun, Liu Tong, Wang Wei, Yuan Zhi*. Qualitative and quantitative evaluation of glycyrrhetinic acid modified alginate liver targeting drug delivery system. Acta Polymerica Sinica. 2011, 8(8): 817-823.
(25)Tian Qin#, Zhang Chuangnian#, Wang Xiuhua, Wang Wei, Huang Wei, Cha Ruitao, Wang Chunhong, Yuan Zhi*, Liu Min, Wan Haiying, Tang Hua*. Glycyrrhetinic acid-modified chitosan/poly(ethylene glycol) nanoparticles for liver-targeted delivery. Biomaterials. 2010, 31(17): 4748-4756.
(26)Zhang Chuangnian, Wang Wei, Wang Chunhong, Tian Qin, Huang Wei, Yuan Zhi*, Chen Xuesi. Cytotoxicity of liver targeted drug-loaded alginate nanoparticles. Science in China Series B-Chemistry. 2009, 52(9): 1382-1387.

授权发明专利：
(1)张闯年; 王晓莉; 孔德领; 孙洪范; 裴萌月; 徐蓉. 一种应用于肝癌免疫治疗的抗原和佐剂共递送纳米疫苗. 授权公告日：2022.3.21. 授权公告号：CN110585426B.
(2)张闯年; 王晓莉; 孔德领; 孙洪范; 裴萌月; 徐蓉. 一种应用于肝癌免疫治疗的抗原和佐剂共递送纳米疫苗的制备方法. 授权公告日：2022.3.21. 授权公告号：CN110585425B.
(3)冯祖建; 王伟伟; 黄平升; 张闯年. 可生物降解紫外光固化医用粘合剂及其制备方法和应用. 授权公告日：2022.12.13. 授权公告号：CN114558166B.
(4)王晓莉; 张闯年; 杨菁; 徐蓉; 柳凯静. 基于纳米颗粒的活细胞表面改造方法及其使用的纳米颗粒. 授权公告日：2022.12.06. 授权公告号：CN112807289B.
(5)王晓莉; 张闯年; 姜艳军; 马桂蕾; 董莹. 一种载有纳米颗粒的微米颗粒疫苗载体的制备方法. 授权公告日：2022.10.14. 授权公告号：CN110025777B.
(6)王晓莉; 张闯年; 裴萌月; 梁佳怡; 徐蓉; 马桂蕾; 孙洪范. 一种片状磷酸钙疫苗佐剂及其制备方法. 授权公告日：2022.07.26. 授权公告号：CN109908339B.
(7)王伟伟; 刘文帅; 冯祖建; 黄平升; 孔德领; 张闯年. 一种抗菌糖肽水凝胶的制备方法. 授权公告日：2022.06.10. 授权公告号：CN113214507B.
(8)李宸; 张闯年; 张明明; 周志敏. 醛基化菊糖及其制备方法和应用. 授权公告日：2022.03.15. 授权公告号：CN112661870B.
(9)宋会娟; 王伟伟; 张闯年; 黄平升; 孔德领. 共组装表位疫苗及其应用. 授权公告日：2022.03.01. 授权公告号：CN110339352B.
(10)刘文帅; 王伟伟; 孔德领; 黄平升; 张闯年. 一种兼具抗菌修复性能的纳米凝胶及其制备方法与应用. 授权公告日：2021.08.24. 授权公告号：CN111234163B.
(11)Zhi Yuan; Wei Huang; Qin Tian; Chuangnian Zhang; Liang Han; Tong Liu; Yue Zhang; Yue Chen. Glycyrrhetinic acid-mediated nanoparticles of hepatic targeted drug delivery system, process for preparing the same and use thereof. Date of Patent: Nov. 3, 2015, Patent No.: US 9,173,852 B2.
(12)袁直; 王蔚; 田秦; 王秀华; 黄微; 张闯年. 一种壳聚糖基肝靶向纳米粒子给药系统及其制备方法. 授权公告日：2012.05.23. 授权公告号：CN101642573B.
(13)袁直; 田秦; 张闯年; 黄微; 贺晓婷; 刘通; 张跃; 陈跃. 甘草次酸－聚乙二醇/壳聚糖肝靶向复合给药系统及制备方法. 授权公告日：2010.09.15. 授权公告号：CN101254308B.
(14)袁直; 黄微; 张闯年; 田秦; 韩亮; 刘通; 张跃; 陈跃. 纳米肝靶向两亲性嵌段共聚物给药系统及制备方法. 授权公告日：2010.06.02. 授权公告号：CN101249266B.

*以上信息由高级会员个人更新和维护。