瑕瑜

女， 清华大学， 教授/研究员/教授级高工或同等级别

学习/工作经历

1999年本科毕业于兰州大学化学系，2002年获得中科院上海药物所硕士学位，2006年于普渡大学 (Purdue University) 化学系取得博士学位。2009-2017年于普渡大学化学系任助理教授、副教授，2016 起任清华大学化学系教授。

研究领域和兴趣

生物质谱分析，脂质组学

主要业绩

瑕瑜课题组致力于开发新型质谱方法与仪器以服务于生物分析。当前研究聚焦于利用溶液中或气相中的自由基与光化学反应，增强串联质谱（MS/MS）对蛋白及脂质等重要生物分子的深度结构表征能力。其团队发展了一系列脂质双键位置异构体的定性定量分析方法并积极推动脂质异构体分析在生物医学的应用。在本领域重要期刊包括Nat Commun, PNAS，JACS, Angew Chem, Anal Chem 等发表论文150余篇。曾获美国质谱学会（ASMS）研究奖，现任中国化学会有机分析专业委员会副主任委员，国际脂质组学会（ILS）副主席，国际质谱学会（IMSF）理事会亚太地区联系人， Journal of Mass Spectrometry编辑及Journal of Lipid Research 编委。

代表成果

1. J. Zhao#, X. Dong#, W. Wan#, L. Qiao, K. Yang*, Y. Xia*, Revealing the Hydrophobic Interactions between Annular Lipids and Transmembrane Peptides via Photo-Tagging and Mass Spectrometry, J. Am. Chem. Soc. 2026, 148, 27638–27647

2. Y. Wang#, G. Sun#, Y. Hang*, Y. Xia*, Deep Profiling Reveals Coordinated Remodeling of Ganglioside Metabolism in Breast Cancer Cell Line, Chem. Sci., 2026, 17, 6488–6499

3. Z. Wang, D. Zhang, J. Wu, W. Zhang, Y. Xia*, “Illuminating the dark space of neutral glycosphingolipidome by selective enrichment and profiling at multi-structural levels”, Nat. Commun., 2024, 15, 5627

4. T. Xia, F. Zhou, D. Zhang, X. Jin, H. Shi, H. Yin, Y. Gong, and Y. Xia*, “Deep-profiling of phospholipidome via rapid orthogonal separations and isomer-resolved mass spectrometry”, Nat. Commun., 2023,14, 4263.

5.X. Zhao, J. Liang, Z. Chen, Y. Wang, Z. Guo, W. Zhang, H. Yin, Y. Xia*, “sn-1 Specificity of Lysophosphatidylcholine Acyltransferase-1 Revealed by a Mass Spectrometry-based Assay”, Angew. Chem. Int. Ed., 2023, 62, e202215556

6. W. Zhang, D. Zhang, Q. Chen, J. Wu, Z. Ouyang*, Y. Xia* “Online photochemical derivatization enables comprehensive mass spectrometric analysis of unsaturated phospholipid isomers” Nat. Commun., 2019, 10, 795

7. S. Adhikari, R. Crehuet, J.M. Anglada*, J.S. Francisco*, Y. Xia*, “Two-Step Reaction Mechanism Reveals New Antioxidant Capability of Cysteine Disulfides against Hydroxyl Radical Attack”, Proc. Natl. Acad. Sci. USA, 2020, 117, 18216-18223

8. X. Zhao, W. Zhang, D. Zhang, X. Liu, W. Cao, Q. Chen, Z. Ouyang, Y. Xia*, “A Lipidomic Workflow Capable of Resolving sn- and C=C Location Isomers of Phosphatidylcholines”, Chem. Sci., 2019, 10, 10740-10748

9. X. Ma, L. Chong, R. Tian, R. Shi, T. Y. Hu, Z. Ouyang*, Y. Xia*, “Identification and quantitation of lipid C=C location isomers: a shotgun lipidomics approach enabled by photochemical reaction”, Proc. Natl. Acad. Sci. USA, 2016, 113, 2573-2578.

10. X. Ma and Y. Xia*, “Pinpointing Double Bonds in Lipids by Paternò–Büchi Reactions and Mass Spectrometry”, Angew. Chem., Int. Ed, 2014, 53, 2592-2596.

*以上信息由高级会员个人更新和维护。