赵建强

男， 成都大学高等研究院， 教授/研究员/教授级高工或同等级别

学习/工作经历

2007.09—2011.07，东北林业大学，学士
2011.09—2016.07，中国科学院大学， 博士
2016.07—2020.12，成都大学高等研究院，助理研究员
2021.01—2025.12，成都大学高等研究院，副研究员
2024.03—2025.03，新加坡国立大学，访问学者
2026.01—至今，成都大学高等研究院，研究员

研究领域和兴趣

不对称催化

主要业绩

本人长期致力于有机合成方法学、手性药物创制及产业化应用研究，形成了系统的研究方向。作为项目负责人，主持国家自然科学基金青年科学基金项目、面上项目各1项，省部级科研项目2项，并参与多项国家级和省部级重点项目。依托上述项目支持，已在国际知名学术期刊ACS Catalysis、Chem. Catalysis等发表SCI论文近120余篇，其中以通讯作者身份发表论文50余篇，总引用次数已超过3500次，其中多篇论文被领域内知名学者多次引用。授权PCT美国专利1项、中国发明专利20余项。2020年荣获成都大学优秀青年教师“青椒计划—青年科研新锐”荣誉；2024和2025年连续获评wiley中国高贡献作者荣誉；2025年入选四川省学术与技术带头人后备人选。带领团队与公安部展开深度合作，成功研发多款具备完全自主知识产权的涉案毒物氘代内标物，包括地西泮-D5、对甲硫磷-D6、阿普唑仑-D3、2'-氯地西泮-D3等一系列关键标准品。该类内标物的研制与应用，为我国法庭科学毒物分析领域的质量控制提供了坚实的技术支撑，显著提升了毒物检测的准确性与可靠性，奠定了行业技术创新的重要基础。先后成功完成了环丙贝特、他唑巴坦、盐酸苄丝肼、克拉霉素、盐酸坦索罗辛、汉防己甲素等多个药物关键中间体的绿色合成工艺研发与优化，经济效益显著。

代表成果

1. Jian-Qiang Zhao*, Liang Wei Benjamin Yep, Bin-Miao Yang, Yu Zhao*. Advances in catalytic enantioconvergent
construction of carbon-nitrogen bonds. Chem Catalysis 2025, 6, 101583; 10.1016/j.checat.2025.101583.
2. Hui-Ling Qian, Hong-Dan Deng, Saisai Yu, Lei Yang, Zhen-Hua Wang, Yong You, Yu Zhao, Shengwen Yang*, Wei-Cheng Yuan*, Jian-Qiang Zhao*. Enantioselective Dearomatization–Rearomatization Strategy to Access Tertiary Alkyl Fluorides. ACS Catal. 2025, 15, 19343-19355; 10.1021/acscatal.5c05643.
3. Hui-Ling Qian, Hong-Dan Deng, Lei Yang, Zhen-Hua Wang, Yong You, Wenjing Zhang*, Wei-Cheng Yuan*, Jian-Qiang Zhao*. Copper-Catalyzed Enantioselective 1,3-Dipolar Cycloaddition Enabled by a Ketimine-Based Umpolung Strategy. ACS Catal. 2025, 15, 17591-17602; 10.1021/acscatal.5c06243.
4. Qiao-Qiao Peng, Xing Yang, Xi-Sha Xue, Juan Liao, Lei Yang, Yong You, Zhen-Hua Wang, Lili Zhao*, Wei-Cheng Yuan*, Jian-Qiang Zhao*. Catalytic enantioselective divergent reaction of thioimidates with naphthols: construction of
N,S-acetal-containing tetrasubstituted carbon centers. Org. Chem. Front. 2025, 12, 4514-4524; 10.1039/d5qo00430f.
5. Pei-Hao Dou, Xiao-Hui Fu, Yan Chen, Zhen-Zhen Ge, Ming-Qiang Zhou, Zhen-Hua Wang, Yong You, Lei Yang, Yan-Ping Zhang, Jian-Qiang Zhao*, Wei-Cheng Yuan*. Palladium-Catalyzed Asymmetric Decarboxylation of 5‑Vinyloxazolidine-2,4-Diones Triggering the Dearomatization of Electron-Deficient Indoles for the Synthesis of Chiral Highly Functionalized Pyrroloindolines. Org. Lett. 2024, 26, 3310-3315; 10.1021/acs.orglett.4c01003.
6. Yao-Bin Shen, Hui-Ling Qian, Lei Yang, Shun Zhou, Han-Wen Rao, Zhen-Hua Wang, Yong You, Yan-Ping Zhang, Jun-Qing Yin, Jian-Qiang Zhao*, Wenjing Zhang*, Wei-Cheng Yuan*. Cu-Catalyzed Direct Asymmetric Mannich Reaction of
2‑Alkylazaarenes and Isatin-Derived Ketimines. Org. Lett. 2024, 26, 1699−1704; 10.1021/acs.orglett.4c00227.
7. Jun-Rui Zhuo, Jian-Qiang Zhao*, Lei Yang, Yu-Lu Wu, Yan-Ping Zhang, Yong You, Zhen-Hua Wang, Ming-Qiang Zhou, Wei-Cheng Yuan*. Thiol-Triggered Tandem Dearomative Michael Addition/ Intramolecular Henry Reaction of 2‑Nitrobenzofurans: Access to Sulfur-Containing Polyheterocyclic Compounds. Org. Lett. 2024, 26, 2623-2628; 10.1021/acs.orglett.4c00646.
8. Jian-Qiang Zhao*, Xue-Man Zhang, Yu-Ying He, Qiao-Qiao Peng, Han-Wen Rao, Yan-Ping Zhang, Zhen-Hua Wang, Yong You, and Wei-Cheng Yuan*. Catalytic Asymmetric Synthesis of Vicinally Bis(trifluoromethyl)-Substituted Molecules via Normal [3 + 2] Cycloaddition of N‑2,2,2-Trifluoroethyl Benzothiophene Ketimines and β‑Trifluoromethyl Enones. Org. Lett. 2023, 25, 8027-8032; 10.1021/acs.orglett.3c03252.
9. Qing Bao, Ting-Jia Sun, Yan-Ping Zhang, Zhen-Hua Wang,Yong You, Zhen-Zhen Ge, Ming-Qiang Zhou, Jian-QiangZhao *, Wei-Cheng Yuan *. Palladium-catalyzed enantioselective decarboxylative allylic alkylation of α-benzyl
cyanoacetates: access to chiral acyclic quaternary carbon stereocenters. Org. Chem. Front. 2023, 10, 5971-5977; 10.1039/d3qo01605f.
10. Jianqiang Zhao, Shun Zhou, WeichengYuan, YongYou, Zhenhua Wang. 1,4-SULFUR-BRIDGED POLYCYCLIC
COMPOUNDS CONTAINING DIHYDROBENZOFURAN STRUCTURE,ITS PREPARATIONMETHODAND APPLICATIONTHEREOF. 2022-3-18, PCT/CN2022/081576; 2024-12-10, US 12,162,897B2.

*以上信息由高级会员个人更新和维护。