李昆

男， 湖南大学， 教授/研究员/教授级高工或同等级别

学习/工作经历

2005.9-2009.6 山东科技大学(SDUST)，应用化学，本科
2009.9-2014.7 中国科学院上海应用物理研究所(SINAP)，化学，硕博连读 (导师：李迪教授\樊春海院士)
2014.9-2017.9 加州大学河滨分校(UCR)，化学工程，博士后 (导师：Prof. Phillip Christopher)
2017.9-2018.3 加州大学圣芭芭拉分校(UCSB)，化学工程，博士后 (导师：Prof. Phillip Christopher)
2018.4-今 湖南大学(HNU)，化学化工学院/化学生物传感全国重点实验室，教授/博士生导师

研究领域和兴趣

纳米生物传感

主要业绩

李昆教授在国家自然科学基金面上项目、青年项目和湖南省自然科学基金优青项目等多个项目的支持下，在单颗粒传感、监测与调控领域开展了多年有特色的工作。构建单颗粒成像与光谱分析平台，发展等离激元介导纳米模拟酶化学反应的测量方法，揭示光对各个拟酶催化中基元过程的影响机制，提出一系列新型纳米酶、纳米结合酶的合理设计与创制思路，实现对纳米酶的催化活性和反应特异性的调控。以第一作者或通讯作者身份在 JACS、Angew、Chem Sci、Nano Lett、ACS Nano、Anal Chem 等国内外重要学术期刊上发表论文40余篇。任Journal of Analysis and Testing、分析试验室等期刊青年编委。承担省部级以上教改项目3项，发表教改论文6篇。曾获上海市优秀博士学位论文、湖南省优秀硕士学位论文指导教师、全国大学生化学实验创新设计大赛全国特等奖指导教师、湖南省高等教育教学成果奖特等奖等奖励。

代表成果

[1] Wenlong Tan, Jinsong Fan, Pingping Wan, Kun Li*. Fenton-Type and Poulos–Kraut Dual Mechanisms of H2O2 Activation over Peroxidase-Mimicking Nanozymes Identified by Operando Measurements. Nano Letters 2025, 25 (36), 13639–13646 (DOI: 10.1021/acs.nanolett.5c03455)
[2] Pingping Wan, Guanghui Chen, Jinsong Fan, Wenlong Tan, Xu Li, Lang Chen, Kun Li*. Modulating ion migration realizes both enhanced and long-term-stable nanozyme activity for efficient microplastic degradation. Chemical Science 2025, 16 (35), 15955–15963 (DOI: 10.1039/D5SC04247J)
[3] Xu Li, Wenlong Tan, Jinsong Fan, Kun Li*. Surface Au–H Species as Self-Generated Prosthetic Groups of a Formate Dehydrogenase-like Au Nanozyme to Engineer Multienzymatic Activities. ACS Nano 2024, 18 (35), 24162–24172 (DOI: 10.1021/acsnano.4c05516)
[4] Jinsong Fan, Xiyue Zhang, Wenlong Tan, Zhenzhen Feng, Kun Li*. Bioinspired Surface Ligand Engineering Regulates Electron Transfers in Gold Clusterzymes to Enhance the Catalytic Activity for Improving Sensing Performance. Nano Letters 2024, 24 (25), 7800–7808 (DOI: 10.1021/acs.nanolett.4c02175)
[5] Peng Jin^, Sili Lin^, Dongmei Wang*, Jinsong Fan, Qingyun Liu, Kun Li*. Valence-band hybridization endows the reaction specificity of AgPd nanozyme for exclusive peroxidase mimicking and improved sensing performance. Chinese Chemical Letters 2025, 36 (11), 110916 (DOI: 10.1016/j.cclet.2025.110916)
[6] Jing Shang, Siyu Jiang, Pei Zhang, Jinsong Fan, Kun Li*. Highly Sensitive Determination of Copper Ions as MnO2 Etching Inhibitor in Single-Particle Nanoplasmonic Imaging. Analytical Chemistry 2024, 96 (45), 18269–18277 (DOI: 10.1021/acs.analchem.4c04691)
[7] Jinzhao Li^, Wenlong Tan^*, Xu Li, Pei Zhang, Peng Jin, Jinsong Fan, Kun Li*. Silver Ion-Facilitated Singular Poulos–Kraut Mechanism of O–O Heterolysis to Enhance the Light Activation of H2O2 over Peroxidase-Mimicking Photonanozymes. Analytical Chemistry 2023, 95 (33), 12435–12442 (DOI: 10.1021/acs.analchem.3c02095)
[8] Pei Zhang, Bo Shen, Xu Li, Zhou Nie, Kun Li*. Hot hole multiplication from silver plasmon-resonated gold interband transitions for enhanced photoelectrochemical sensing. Chinese Chemical Letters 2023, 34 (12), 108588 (DOI: 10.1016/j.cclet.2023.108588)
[9] Xu Li, Yan Zhang, Wenlong Tan, Peng Jin, Pei Zhang, Kun Li*. Bioinspired Coassembly of Copper Ions and Nicotinamide Adenine Dinucleotides for Single-Site Nanozyme with Dual Catalytic Functions. Analytical Chemistry 2023, 95 (5), 2865–2873 (DOI: 10.1021/acs.analchem.2c04389)
[10] Yan Wang, Song Wang, Ningning Dong, Wenyuan Kang, Kun Li*, Zhou Nie*. Titanium carbide MXenes mediated in situ reduction allows label-free and visualized nanoplasmonic sensing of silver ions. Analytical Chemistry 2020, 92 (6), 4623–4629 (DOI: 10.1021/acs.analchem.0c00164)

*以上信息由高级会员个人更新和维护。