陈海峰

男， 上海交通大学， 教授/研究员/教授级高工或同等级别

学习/工作经历

1990-1994 西安交通大学 本科
1994-1997 四川大学 硕士
1997-2004 中科院上海有机化学研究所 助理研究员
2000-2003 法国巴黎第七大学 博士
2005-2006 美国加州大学尔湾分校 博士后
2007-至今 上海交通大学 教授

研究领域和兴趣

人工智能蛋白质设计

主要业绩

聚焦人工智能全新蛋白质设计、无规蛋白的分子力场及溶剂化模型开发以及人工智能蛋白质药物发现。在JACS，PNAS，Advanced Science等国际期刊发表超过170篇SCI论文。发展了多个无规蛋白的分子力场，开发了人工智能蛋白质设计模型，研发了长效GLP-1减重多肽药物。

代表成果

1.Z. Li, J. Zhu, X. Hong, J. Mu, Z. Zheng, T. Cui, Y. Sun, T. Wei, H.F. Chen*. DynaRNA: Accurate Dynamic RNA Conformation Ensemble Generation with Diffusion Model. Communications Biology. 2025, 8: 1472.
2.J. Zhu, Z. Li, Z. Zheng, B. Zhang, B. Zhong, J. Bai, T. Wang, T. Wei*, J. Yang*, H.F. Chen*. Accurate Generation of Conformational Ensembles for Intrinsically Disordered Proteins with IDPFold. Advanced Science. 2025, 12: e11636.
3.T. Wei, J. Ma, X. Cui, J. Lin, Z. Zheng, T. Cui, L. Cheng, X. Lin, J. Zhu, X. Ran, X. Hong, Z. Yu*, H.F. Chen*. AI-Driven De Novo Design of Ultra Long-acting GLP-1 Receptor Agonists. Advanced Science. 2025, 12: e07044.
4.L. Cheng, T. Wei, X. Cui, H.F. Chen*, Z. Yu*. ProDualNet: Dual-Target Protein Sequence Design Method Based on Protein Language Model and Structure Model. Brief. Bioinformatics. 2025, 26: bbaf391.
5.Z. Li, G. Song, J. Zhu, J. Mu, Y. Sun, X. Hong, T. Choi, X. Cui, H.F. Chen*. Excited-Ground State Transition of RNA Strand Slippage Mechanism Captured by Base-specific Force Field. J. Chem. Theory Comput. 2024, 20: 6082-6097.
6.J. Mu, Z. Li, B. Zhang, Q. Zhang, J. Iqbal, A. Wadood, T. Wei*, Y. Feng*, H.F. Chen*. Graphormer Supervised De Novo Protein Design Method and Function Validation. Brief. Bioinformatics. 2024, 25: bbae135.
7.J. Zhu, Z. Li, H. Tong, Z. Lu, N. Zhang, T. Wei*, H.F. Chen*. Phanto-IDP: Compact Model for Precise Intrinsically Disordered Protein Backbone Generation and Enhanced Sampling. Brief. Bioinformatics. 2024, 25: bbad429.
8.Z. Pan, J. Mu, H.F. Chen*. Balanced Three-point Water Model OPC3-B for Intrinsically Disordered and Ordered Proteins. J. Chem. Theory Comput. 2023, 19: 4837-4850.
9.Y. Zhang, H. Liu, S. Yang, R. Luo*, H.F. Chen*. Well-balanced Force Field ff03CMAP for Folded and Disordered Proteins. J. Chem. Theory Comput. 2019, 15: 6769-6780.
10.H.F. Chen, R. Luo*. Binding induced folding in p53-MDM2 complex. J. Am. Chem. Soc. 2007, 129: 2930-2937.

*以上信息由高级会员个人更新和维护。