肖国志

男， 中国科学院昆明植物研究所， 教授/研究员/教授级高工或同等级别

学习/工作经历

2004-2008 学士
应用化学, 中山大学, 广东, 中国
2008-2013 博士
有机化学, 上海有机化学研究所, 中国科学院, 上海, 中国 （导师：俞飚 研究员，院士）
2013-2015 博士后
马普胶体与界面研究所，生物化学系，德国， 合作导师：Peter H. Seeberger 教授
2015-2017 博士后
威斯康辛大学麦迪逊分校，药学院，美国，合作导师：Weiping Tang 教授
2017 至今 研究员
昆明植物研究所, 中国科学院, 昆明, 中国

研究领域和兴趣

糖化学合成

主要业绩

围绕发展新方法和策略高效合成糖类化合物这一主题开展研究工作，在新的糖基给体，立体选择性调控和复杂糖链及药物全合成三个方面取得了原创性成果。主要包括：1）发展了PVB糖苷化反应和基于糖基PVB一锅糖苷化反应策略，提升了对糖类和核苷类化合物的获取能力；2）建立了融合试剂调控和远程参与的1，2-顺式糖苷化体系，为高效构建1，2-顺式糖苷键提供了新的思路；3）完成了结核分枝杆菌mLAM 101糖和AG 92糖等一系列重要生理活性复杂糖链及药物的一锅法高效合成和功能评价。在Acc. Chem. Res.、Nat. Commun.、J. Am. Chem. Soc.和Angew. Chem. Int. Ed.等期刊发表SCI论文40余篇。曾入选国家优青、云南省“兴滇英才支持计划”云岭学者专项、云南省杰出青年基金项目和中国科学院“BR计划”。曾获得中国化学会首届糖化学青年学者奖和Thieme Chemistry Journals Award。

代表成果

1. Guozhi Xiao*
Glycosyl ortho-(1-phenylvinyl) benzoates as donors for streamlined one-pot assembly of carbohydrates from oligosaccharides to polysaccharides
Acc. Chem. Res. 2025, 58, 2350
2. Jie Wan,+ Yujie Ji,+ Leilei Wang, Rui Yang, Kaifeng Li, Qingyun Xian, Xiufang Wang, Gang Lu*, Guozhi Xiao*
Highly stereoselective 1,2-cis-xylosylation enabled by reagent modulation, remote participation and electron-withdrawing synergistic effects
Angew. Chem. Int. Ed. 2025, e202424048
3. Fuqiang Guo,+ Qiang Tan,+ Jiahui Guo,+ Kaifeng Li, Xiufang Wang*, Wei Cao*, Guozhi Xiao*
Total Synthesis of the Tridecasaccharide Motif from Angelica sinensis APS-1 II Polysaccharide with Anti-leukemia Activity and Structure–Activity Relationship Studies
Angew. Chem. Int. Ed. 2025, e202422887
4. Yuxin Ma,+ Ferran Nieto-Fabregat,+ Hanyingzi Fan,+ Qingyun Xian, Maina Takahashi, Francesca Olmeo, Emanuela Andretta, Kunxiu Shou, Qiang Tan, Yao Ma, Xiufang Wang, Flaviana Di Lorenzo*, Antonio Molinaro, Alba Silipo*, Guozhi Xiao*
Chemical Synthesis of Arabinogalactans from the Mycobacterium tuberculosis Cell Wall up to the 92-mer and Structure-Conformation-Activity Relationship Studies
Angew. Chem. Int. Ed. 2025, e202515896.
5. Zhiyuan Chen, Guozhi Xiao*
Total Synthesis of Nona-decasaccharide Motif from Ganoderma sinense Polysaccharide Enabled by Modular and One-Pot Stereoselective Glycosylation Strategy
J. Am. Chem. Soc. 2024, 146, 17446.
6. Yuxin Ma,+ Yuqin Zhang,+ Zixi Chen, Qingyun Xian, Rui Su, Qiong Jiang, Xiufang Wang, Guozhi Xiao*
One-Pot Assembly of Mannose-Capped Lipoarabinomannan Motifs up to 101-Mer from the Mycobacterium tuberculosis Cell Wall
J. Am. Chem. Soc. 2024, 146, 4112.
7. Yunqin Zhang, Leilei Wang, Qingli Zhou, Zuoshan Li, Dan Li, Caixia Yin, Xiufang Wang, Guozhi Xiao*
Modular synthesis of trisaccharide motif from Bacteroides vulgatus lipopolysaccharides against inflammatory bowel diseases via through an orthogonal one-pot glycosylation strategy
Angew. Chem. Int. Ed. 2023, 62, e202301351.
8. Yunqin Zhang, Haiqing He, Zixi Chen, Yingying Huang, Guisheng Xiang, Penghua Li, Xingkuan Yang, Gang Lu,* Guozhi Xiao*
Merging reagent modulation and remote anchimeric assistance for glycosylation: highly stereoselective synthesis of a-glycans up to a 30-mer
Angew. Chem. Int. Ed. 2021, 60, 12597.
9. Yunqin Zhang+, Zixi Chen+, Yingying Huang+, Shaojun He, Xingkuan Yang, Zhibing Wu, Xiufang Wang,* Guozhi Xiao*
Modular Synthesis of the Nonadecasaccharide Motif of Psidium guajava Polysaccharides: Orthogonal One-Pot Glycosylation Strategy
Angew. Chem. Int. Ed. 2020, 59, 7576.
10. Penghua Li+, Haiqing He+, Yunqin Zhang+, Rui Yang, Lili Xu, Zixi Chen, Yingying Huang, Limei Bao, Guozhi Xiao*
Glycosyl ortho-(1-phenylvinyl)benzoates versatile glycosyl donors for highly efficient synthesis of both O-glycosides and nucleosides
Nat. Commun. 2020, 11, 405.

*以上信息由高级会员个人更新和维护。