分会

第四十四分会：纳米碳材料

摘要

磷酸盐辅助合成的红色荧光碳点用于光动力学治疗 徐雅兰，贺依民，王婵*，宋启军* 江南大学 化学与材料工程学院，无锡，214122 *Email: wangchan@jiangnan.edu.cn ;qsong@jiangnan.edu.cn 光动力学治疗（PDT）是利用光敏剂吸收的能量传递给的氧气，以生成活性强的单线态氧（1O2），并将其用于癌症诊疗的一种手段，具有实施方便、创伤小、选择性好等特点。然而，传统光敏剂光稳定性较差、1O2产率较低，其中吩噻嗪类光敏剂（如亚甲基蓝）易与DNA的磷酸基团结合，产生致癌副作用。本课题组从开发新型光敏剂、提高1O2产率出发，以亚甲基蓝为碳源，磷酸盐辅助水热合成了红色荧光碳点（R-CDs），所得R-CDs的水溶性优异、光稳定性好、1O2产率高（0.75），同时由于磷酸基团的引入，克服了DNA被侵染的缺点。 Phosphate-assisted synthesis of red fluorescent carbon dots for photodynamic therapy Yalan Xu, Yimin He, Chan Wang*, Qijun Song* School of Chemical＆Material Engineering, Jiangnan University, Wuxi, 214122 A new kind of red emissive carbon dots (R-CDs) was prepared hydrothermally by using methylene blue (MB) as the sole carbon source in KH2PO4 solution. The resultant R-CDs exhibit excellent water solubility, photostability and high singlet oxygen (1O2) yield (0.75), thus they have been successfully applied to the PDT study in vitro. More importantly, the R-CDs show non-infective property to DNA, which is substantially different to their precursor MB. The structure of R-CDs was comprehensively characterized both experimentally as well as by density functional theory (DFT) calculation. This study not only provides a rational strategy for preparation of highly efficient PDT material, but also gives an insight into the mechanism of 1O2 generation.

关键词

红色荧光碳点（R-CDs）；光动力学治疗（PDT）；单线态氧（1O2）

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